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The Scientific World Journal
Volume 2017, Article ID 9320802, 5 pages
Research Article

Serum Glutamate Is a Predictor for the Diagnosis of Multiple Sclerosis

1Department of Neurology, Baghdad Teaching Hospital, Medical City, College of Medicine, University of Baghdad, Baghdad, Iraq
2Department of Microbiology & Immunology, College of Medicine, University of Baghdad, Baghdad, Iraq

Correspondence should be addressed to Inas K. Sharquie; moc.oohay@eiuqrahski

Received 6 March 2017; Revised 3 May 2017; Accepted 9 May 2017; Published 6 June 2017

Academic Editor: Maria Grazia Grasso

Copyright © 2017 Gheyath Al Gawwam and Inas K. Sharquie. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


One neurotransmitter, glutamate, has been implicated in the autoimmune demyelination seen in multiple sclerosis (MS). Glutamate is present in many tissues in the body, so consideration should be given to whether the serum level of glutamate is likely well correlated with the activity of the disease. This research aimed to compare the serum glutamate levels from patients diagnosed with MS with those from an age-matched control population. A review of this data could shed light upon whether the serum testing of glutamate using Enzyme-Linked Immunosorbent Assay (ELISA) is a reliable indicator of MS activity. Serum samples were obtained from 55 patients with different patterns of MS and from 25 healthy adults as a control group. The ELISA technique was used to determine the glutamate levels in the serum samples. The mean serum glutamate level for patients with MS was  nmol/ml and that of the controls was  nmol/ml. The serum glutamate levels showed an area under the curve via the receiver operating characteristics (ROC) of 0.738, which was significant (p value = 0.001). The present study is the first to establish a strong connection between the serum glutamate levels and MS patients, where there was statistically significant elevation of serum glutamate in MS patients; hence this elevation might be used as a monitor to help in the diagnosis of MS patients.