Table 3: Clinical trials on the effectiveness of Matricaria.

ReferenceInterventionJadadscoreResults

[11]Kamillan Liquidum solution made from chamomile flowers4↓ in the appearance of oral mucositis in 85% of the patients
↑ immediate relief of painful symptomatology
↑ reepithelialization of the desquamated tissue

[12]Chamomile concentrate5Degree of oral mucositis < in the male gender
No significant difference (treated versus placebo groups)

[13]Infusion with 8 g of dried flowers with 20 ml of water-↓ in the oral mucositis grade III on the 13th day
30th day complete absence of mucositis

[14]Gel with 3% of chamomile extract3↓ discomfort and severity of oral mucositis
↓ treatment time
It was not effective in preventing

[8]Oral antiseptic with 0.5%, 1%, and 2% of chamomile extract5Significant results found in the dosage of 1%
↓ incidence
↓ intensity of injuries
↓ oral mucositis duration

[15]3 ml of chamomile mouthwash added to the half cup of water3↓ pain
↓ incidence

[16]Oral antiseptic with 1% of chamomile extract and 1% of5↓ pain
↓ dryness of the oral cavity
↓ dysphagia

[17]Ice with 400 ml of water and 10 g of chamomile flowers4↓ incidence of oral mucositis
↓ painful symptomatology
↓ presence of ulcerations

[18]Chamomile Orobase5↓ intensity of pain
↓ the size of the lesion

[19]15 drops of chamomile solution diluted in a glass of water0↓ incidence
↓ gravidity

[20]30 ml of chamomile4↓ incidence
↓ gravidity

↓: reduction; ↑: increase.