Table 4: Articles included in the review organized in chronological order of publication: authors, animal experiment, study groups, intervention, duration of the experiment, and results.

ReferenceAnimalExperimentStudy groupsInterventionDuration of the experimentResults

[21]Albino male rats (Wistar)Mucosal ulceration left by abrasion with scalpel blade and marker of 8 mm diameterGroup 1. Treated with saline
Group 2. Treated with chamomile extract
Group 3. Treated with triamcinolone
NC10 daysEpithelium refurbished absence of inflammation
↑ collagen deposition
↓ apoptosis and TNF-α

[22]Albino male rats (Wistar)Injury with 1 mm of depth in the central region of the tongueGroup 1. Chamomile ointment
Group 2. Without treatment
Topical application of 2 ml chamomile extract with concentration of 10%10 days↑ epithelialization and collagenous fibers
↑ fibroblasts
↓ inflammation

[23]Female albino rats (Wistar)Intraperitoneal administration of 5-FluorouracilGroup 1. Distilled water management
Group 2. Chamomile extract
Probe intragastric administration of the alcoholic extract of chamomile12 days↓ toxicity caused by medicine
↓ size of the lesion prolonged use caused toxicity in the mucosa of the tongue

[24]Female albino mice (Swiss)Application of injection of carrageenan on hind right mouseGroup 1. Saline
Group 2. Chamomile
MeOH extract of chamomile16 days↓ development of arthritis
↓ histamine
↓ inflammation

[25]Albino male rats (Wistar)The animals were trichotomized with an electric razor in an area of skin back approximately 10 cmGroup 1. Ethanolic extract of Chamomile
Group 2. Crude extract of Chamomile
Topical application in skin of Wistar rats with carrageenan-induced paw edema12 daysNot provide anti-inflammatory action on the induced edema

[9]Male Golden Syrian hamstersIntraperitoneal administration of 5-FluorouracilGroup 1. Without treatment
Group 2. Chamomile
Group 3. Corticosteroids
Ointment with 100 g of chamomile extract14 days↑ levels of TNF-α on the 5th day
↓ severity
↓ levels of IL-1β and TNF-α

[26]Female Syrian Golden hamstersIntraperitoneal administration of 5-FluorouracilGroup 1. Without treatment
Group 2. Chamomile
Group 3. Corticosteroids
Ointment with 100 g of chamomile extract16 days↓ incidence of oral mucositis
↓ severity
↓ vascular hyperemia
↓ inflammatory infiltration

[27]Albino male rats (Wistar)Intraperitoneal administration of 5-FluorouracilGroup 1. Without treatment
Group 2. Chamomile
Ointment with 10% of chamomile extract10 days↑ reepithelialization
↑ collagen fibers
↓ of the inflammatory process
↓ on wound size

[28]Albino male rats (Wistar)Traumatic ulcers on tongue with 3 mm diameterGroup 1. Without drugs
Group 2. Chamomile
Group 3. Acetone of triamcinolone topical
Topical formulation of Chamomile14 days↑ healing
↑ repair of the epithelium and connective tissue total in 5 days
↓ inflammatory cells

[29]Albino male rats (Wistar)Immersion in boiling water for 8 seconds, resulting in burning of 20% of the body areaGroup 1. Without treatment
Group 2. Application of olive oil
Group 3. Chamomile
Chamomile flowers folder added to olive oil67 days↑ tissue regeneration
↓ inflammatory infiltration

UI: uninformed; ↓: reduction; ↑: increase; TNF: tumor necrosis factor; IL: interleukin.