Preeclampsia in 2018: Revisiting Concepts, Physiopathology, and Prediction

Table 1

Preeclampsia prediction potential of biomarkers and maternal characteristics.

Biomarker	AUC (95CI)	Reference
Maternal characteristics	0.78 (0.71-085)	Goetzinger et al. [12]
PAPP-A	0.64 (0.57-0.72)	Goetzinger et al.
ADAM-12	0,58 (0.50-0.67)	Goetzinger et al.
Maternal characteristics +PAPP-A+ADAM-12	0.79 (0.71-0.86)	Goetzinger et al.
PlGF	0.61 (0.56-0.66)	Myatt et al. [13, 14]
PAPP-A	0.54 (0.49-0.59)	Myatt et al.
ADAM-12	0.58 (0.53-0.63)	Myatt et al.
Maternal; characteristics+PlGF+PAPP-A+ADAM-12	0.73 (0.69-0.77)	Myatt et al.
sFlt-1	0.54 (0.48-0.59)	Myatt et al.
PP13	0.51 (0.46-0.56)	Myatt et al.

Considered maternal characteristics: African-American ethnicity, body mass index, pregestational diabetes mellitus; Considered maternal characteristics: African-American ethnicity, body mass index, systolic blood pressure, and educational level; PAPP-A, pregnancy-associated plasma protein A; ADAM-12, A Disintegrin and Metalloprotease 12; PlGF, placental growth factor; sFlt-1, soluble fms-like tyrosine kinase 1; PP13, placental protein 13; AUC, area under the curve.