Factors Influencing Hemoglobin Variability and Its Association with Mortality in Hemodialysis Patients
Table 2
Biochemical parameters and medications of hemoglobin variability.
Patient characteristics
HA (: 39)
High (: 13)
Target (: 42)
Low (: 37)
LAH (: 16)
LAL (: 22)
Hemoglobin (g/dl)
10.7 ± 0.7
12.7 ± 0.8
11.1 ± 0.4
9.9 ± 0.8
12.2 ± 1.0
9.6 ± 0.6
0.001
Hb-var (g/dl)
1 (0.4)
0.7 (0.3)
0.8 (0.3)
0.8 (0.2)
1 (0.1)
0.9 (0.2)
0.001
Maximum Hb-var (g/dl)
4 (1.5)
2.4 (1.2)
2.5 (0.8)
2.6 (1.3)
3.9 (1.1)
3.6 (0.8)
0.001
Coefficient of Hb-var
9.3 (4.1)
5.9 (2.8)
7.3 (2.7)
7.8 (2.8)
8.4 (1.5)
10.1 (2.9)
0.001
MCV (fl)
90.1 ± 3.9
89.1 ± 4.2
91.2 ± 4.6
91.5 ± 5.2
86.8 ± 6.8
88.1 ± 7.0
0.017
RDW (%)
16.5 (2.4)
16.3 (2.2)
15.8 (1.5)
16.0 (1.2)
16.9 (1.6)
16.1 (1.6)
0.085
Leukocyte (×103/µl)
7.0 ± 1.7
6.4 ± 1.3
6.7 ± 1.6
5.9 ± 1.7
7.3 ± 2.1
6.9 ± 1.6
0.05
Calcium (mg/dl)
9.4 ± 0.6
9.0 ± 0.6
9.2 ± 0.6
9.2 ± 0.8
9.2 ± 0.9
8.8 ± 0.6
0.135
Phosphate (mg/dl)
5.7 ± 1.5
5.3 ± 0.4
5.0 ± 1.2
5.1 ± 1.4
5.0 ± 1.1
5.1 ± 1.0
0.239
Albumin (g/dl)
4.0 ± 0.3
4.3 ± 0.3
4.1 ± 0.3
4.1 ± 0.3
4.2 ± 0.6
4.1 ± 0.4
0.144
CRP (mg/l)
9.7 (13)
4.7 (6)
9.7 (15)
7.6 (14)
11.2 (10)
7.5 (22)
0.744
Transferrin saturation%
29.7 (12)
35.5 (14)
32.3 (13)
29.2 (23)
28.5 (17)
29.0 (17)
0.907
Ferritin (µg/l)
275 (400)
124 (86)
310 (222)
382 (298)
196 (248)
462 (400)
0.001
PTH (pg/ml)
445.7 (728)
303.7 (400)
281.3 (508)
491.2 (1078)
214.4 (515)
299.7 (401)
0.118
URR%
66.2 ± 5.3
65.4 ± 4.6
66.1 ± 6.5
67.7 ± 6.7
64.4 ± 6.3
65.5 ± 8.5
0.600
MIS
7 (4)
5 (5)
7 (4)
6 (3.5)
7 (2.8)
7.5 (4)
0.471
ESA total dose per body weight (U/kg)
3.3 (3.4)
0.3 (0.6)
3.0 (2.4)
4.9 (1.4)
0.5 (1.6)
5.1 (2.1)
0.001
Iron per body weight (mg/kg)
15.7 (25)
14.7 (27)
13.4 (16)
16.5 (19)
18.2 (19)
11.7 (20)
0.167
Months of hb < 11 g/dl
6.5 ± 2.3
0.5 ± 0.6
4.3 ± 2.0
9.9 ± 1.7
2.2 ± 2.4
10.4 ± 1.2
0.001
10 year survival
21 (77)
21 (56)
21 (77)
53 (76)
21 (69)
53 (77)
0.851
HA: high-amplitude fluctuation; LAH: low-amplitude fluctuation with high hemoglobin; LAL: low-amplitude fluctuation with low hemoglobin; Hb-var (hemoglobin variability); MCV: mean corpuscular volume: RDW: red blood cell distribution width; CRP: C-reactive protein; PTH: parathyroid hormone; URR: urea reduction ratio; MIS: malnutrition-inflammation score; ESA: erythropoiesis-stimulating agents. Median (Interquartile range); other results are given as mean ± standard deviation.
