Table 2: Biochemical parameters and medications of hemoglobin variability.

Patient characteristicsHA (: 39)High (: 13)Target (: 42)Low (: 37)LAH (: 16)LAL (: 22)

Hemoglobin (g/dl)10.7 ± 0.712.7 ± 0.811.1 ± 0.49.9 ± 0.812.2 ± 1.09.6 ± 0.60.001
Hb-var (g/dl)1 (0.4)0.7 (0.3)0.8 (0.3)0.8 (0.2)1 (0.1)0.9 (0.2)0.001
Maximum Hb-var (g/dl)4 (1.5)2.4 (1.2)2.5 (0.8)2.6 (1.3)3.9 (1.1)3.6 (0.8)0.001
Coefficient of Hb-var9.3 (4.1)5.9 (2.8)7.3 (2.7)7.8 (2.8)8.4 (1.5)10.1 (2.9)0.001
MCV (fl)90.1 ± 3.989.1 ± 4.291.2 ± 4.691.5 ± 5.286.8 ± 6.888.1 ± 7.00.017
RDW (%)16.5 (2.4)16.3 (2.2)15.8 (1.5)16.0 (1.2)16.9 (1.6)16.1 (1.6)0.085
Leukocyte (×103/µl)7.0 ± 1.76.4 ± 1.36.7 ± 1.65.9 ± 1.77.3 ± 2.16.9 ± 1.60.05
Calcium (mg/dl)9.4 ± 0.69.0 ± 0.69.2 ± 0.69.2 ± 0.89.2 ± 0.98.8 ± 0.60.135
Phosphate (mg/dl)5.7 ± 1.55.3 ± 0.45.0 ± 1.25.1 ± 1.45.0 ± 1.15.1 ± 1.00.239
Albumin (g/dl)4.0 ± 0.34.3 ± 0.34.1 ± 0.34.1 ± 0.34.2 ± 0.64.1 ± 0.40.144
CRP (mg/l)9.7 (13)4.7 (6)9.7 (15)7.6 (14)11.2 (10)7.5 (22)0.744
Transferrin saturation%29.7 (12)35.5 (14)32.3 (13)29.2 (23)28.5 (17)29.0 (17)0.907
Ferritin (µg/l)275 (400)124 (86)310 (222)382 (298)196 (248)462 (400)0.001
PTH (pg/ml)445.7 (728)303.7 (400)281.3 (508)491.2 (1078)214.4 (515)299.7 (401)0.118
URR%66.2 ± 5.365.4 ± 4.666.1 ± 6.567.7 ± 6.764.4 ± 6.365.5 ± 8.50.600
MIS7 (4)5 (5)7 (4)6 (3.5)7 (2.8)7.5 (4)0.471
ESA total dose per body weight (U/kg)3.3 (3.4)0.3 (0.6)3.0 (2.4)4.9 (1.4)0.5 (1.6)5.1 (2.1)0.001
Iron per body weight (mg/kg)15.7 (25)14.7 (27)13.4 (16)16.5 (19)18.2 (19)11.7 (20)0.167
Months of hb < 11 g/dl6.5 ± 2.30.5 ± 0.64.3 ± 2.09.9 ± 1.72.2 ± 2.410.4 ± 1.20.001
10 year survival21 (77)21 (56)21 (77)53 (76)21 (69)53 (77)0.851

HA: high-amplitude fluctuation; LAH: low-amplitude fluctuation with high hemoglobin; LAL: low-amplitude fluctuation with low hemoglobin; Hb-var (hemoglobin variability); MCV: mean corpuscular volume: RDW: red blood cell distribution width; CRP: C-reactive protein; PTH: parathyroid hormone; URR: urea reduction ratio; MIS: malnutrition-inflammation score; ESA: erythropoiesis-stimulating agents. Median (Interquartile range); other results are given as mean ± standard deviation.