T-Bet Is Dependent on Stat-4 Inhibiting Acute Colitis but Not Stat-1 Using L4 Somatic Antigen of Heligmosomoides polygyrus

Figure 2

LSA instillation effects on mice with DNBS-induced colitis. Data were obtained from five independent experiments (n = 5), each of which contained five mice (total n = 25, error bar = SD). Body weight loss was observed in mice without LSA instillation (Group II) and Groups III–V were injected with different concentration of LSA. Mice of Group II (DNBS only) showed significant body weight loss compared to LSA-injected mice (a: p < 0.05), whereas Group V (LSA 200 μg/mL) injected mice weights were not significantly decreased compared to control. b: p < 0.001. Representative results obtained from five independent experiments are shown (ns: not significant).