Mechanical Transformation of Compounds Leading to Physical, Chemical, and Biological Changes in Pharmaceutical Substances

Table 1

The lactose monohydrate solubility rate constants and kinetic isotopic effect in water with different D/Н ratios for native and dispersed substances.

Lactose monohydrate sample	∙10^2., s^-1; n = 3, Р = 95%		∙10^2, s^-1; n = 1
	ddw; D/H = 4 ± 0.9 ppm	MilliQ; D/H = 140 ± 0.9ppm	D2O; 99,9 %
Native substance	2.25 ± 0.089	1.36 ± 0.144	0.80	1.6	2.8	1.7
Dispersed substance	3.46 ± 0.199	2.26 ± 0.215	0.88	1.5	3.9	2,6