Review Article
Fetal Growth Restriction Prediction: How to Move beyond
Table 2
Accuracy for clinical factors, ultrasound parameters, and placental biomarkers for SGA prediction (birthweight <10th centile).
| | Predictive factors | AUC | S (95% CI) | Sp (95% CI) | When |
| | Maternal height [64] | 0.59 | 0.43 (0.27–0.60) | 0.70 (0.53–0.83) | At booking | | Maternal weight [64] | 0.57 | 0.73 (0.60–0.83) | 0.35 (0.23–0.51) | At booking | | Maternal weight gain [64] | 0.60 | 0.50 (0.42–0.59) | 0.66 (0.57–0.73) | At booking | | PAPP-A [43] | | 0.16 (0.14–0.19) | 0.90 (0.89–0.90) | 1st trimester | | PlGF [65] | | 0.49 (0.44–0.53) | 0.64 (0.63–0.66) | 2nd trimester | | Cerebroplacental ratioa [66] | | 0.43 (0.39–0.47) | 0.94 (0.84–0.98) | 3rd trimester | | Estimated fetal weightb [67] | 0.79 | 0.38 (0.31–0.46) | 0.95 (0.93–0.97) | >32 w | | Abdominal circumference [67] | 0.92 | 0.35 (0.20–0.52) | 0.97 (0.95–0.98) | >32 w |
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aMCA-PI/UA-PI <10th centile or ≤1.08; bestimated fetal weight <10th centile for gestational age. AUC: area under the receiver operator characteristic curve; S: sensitivity; Sp: specificity; PAPP-A: pregnancy-associated plasma protein-A; PlGF: placental growth factor.
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