The Scientific World Journal / 2019 / Article / Tab 2

Review Article

Fetal Growth Restriction Prediction: How to Move beyond

Table 2

Accuracy for clinical factors, ultrasound parameters, and placental biomarkers for SGA prediction (birthweight <10th centile).

Predictive factorsAUCS (95% CI)Sp (95% CI)When

Maternal height [64]0.590.43 (0.27–0.60)0.70 (0.53–0.83)At booking
Maternal weight [64]0.570.73 (0.60–0.83)0.35 (0.23–0.51)At booking
Maternal weight gain [64]0.600.50 (0.42–0.59)0.66 (0.57–0.73)At booking
PAPP-A [43]0.16 (0.14–0.19)0.90 (0.89–0.90)1st trimester
PlGF [65]0.49 (0.44–0.53)0.64 (0.63–0.66)2nd trimester
Cerebroplacental ratioa [66]0.43 (0.39–0.47)0.94 (0.84–0.98)3rd trimester
Estimated fetal weightb [67]0.790.38 (0.31–0.46)0.95 (0.93–0.97)>32 w
Abdominal circumference [67]0.920.35 (0.20–0.52)0.97 (0.95–0.98)>32 w

aMCA-PI/UA-PI <10th centile or ≤1.08; bestimated fetal weight <10th centile for gestational age. AUC: area under the receiver operator characteristic curve; S: sensitivity; Sp: specificity; PAPP-A: pregnancy-associated plasma protein-A; PlGF: placental growth factor.

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