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The Scientific World Journal
Volume 2019, Article ID 2561530, 6 pages
https://doi.org/10.1155/2019/2561530
Research Article

Human Papillomavirus Detection in Head and Neck Squamous Cell Carcinomas at a Tertiary Hospital in Sub-Saharan Africa

1Department of Molecular Medicine, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana
2Spectra Health Imaging and Interventional Radiology, Kumasi, Ghana
3Department of Pathology, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana

Correspondence should be addressed to Evans Aboagye; moc.oohay@19eygaobave

Received 17 December 2018; Revised 23 February 2019; Accepted 12 March 2019; Published 2 April 2019

Academic Editor: Stefania Staibano

Copyright © 2019 Evans Aboagye et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Fewer studies have been done over the years to establish the association of human papillomavirus (HPV) with head and neck squamous cell carcinoma (HNSSC) within the subregions of sub-Saharan Africa, and thus this study was designed to investigate the presence of HPV in HNSCC at a tertiary hospital in Ghana, providing additional evidence on the need to explore similar studies in other subregions. A retrospective cross-sectional study was employed to investigate the presence of the DNA of HPV genotypes in HNSCC archived tissue. A total of 100 HNSCC cases were classified as suitable for HPV genotyping. HPV-DNA was detected in 18% of the HNSCC cases, with 17 being HPV-16 and 1 dual infection with HPV-16 and HPV-18. HPV was prevalent in 50% of oropharyngeal cancers, 27% of laryngeal cancers, and 23% of oral cavity cancers. HPV E6/E7 oncogenic DNA was found in 18% of the HNSCC cases, with HPV-16 being the predominant genotype present. The pattern of HPV association was similar to earlier reported studies, recording a higher prevalence in oropharyngeal cancers, followed by laryngeal cancers and oral cavity cancers.