Long-Term Outcomes of Mechanical Thrombectomy for Stroke: A Meta-Analysis

Table 1

Included trials and their respective study designs.

	Trial	IMS III	MR CLEAN	REVASCAT
Enrollment Criteria	Publication year	2013	2015	2015
	Time period	2006-2012	2010-2014	2012-2014
	Location	North America, Europe, Australia	Netherlands	Spain
	No. of Centers	58	16	4
	No. of Patients	656	500	206
	Last known well to randomization, h	≤5	≤6	≤8
	Age, y	≥18	≥18	18-85
	NIHSS score	≥10, or ≥8 with LVO	≥2	≥6
	LVO	NA	ICA, MCA (M1/ M2) ACA (A1/ A2)	ICA, MCA (M1)
	ASPECTS	NA	NA	≥7, CT; ≥6, MRI
	Endovascular intervention	IA thrombectomy, IA-tPA, IV-tPA	IA thrombectomy, IA-tPA, IV-tPA	IA thrombectomy, IV-tPA
	Control arm	IV-tPA	IV-tPA	Standard therapy
	Primary endpoint	mRS ≤2 at 1 y	mRS at 2 y	mRS at 1 y
	Follow-up duration	1 y	2 y	1 y

ACA, anterior cerebral artery; ASPECTS, Alberta Stroke Program Early CT score; CTA, CT angiography; d, days; IA, intra-arterial; ICA, internal carotid artery; LVO, large vessel occlusion; MCA, middle cerebral artery; mRS, modified Rankin Scale; NA, not applicable; No., number; tPA, tissue plasminogen activator
After 284 patients enrolled, protocol altered to no upper limit for age, identification of occlusion with CTA was allowed for patients with NIHSS score of 8 or 9
ASPECTS <4 used as guideline when evaluating >1/3 region of territory involvement, but not exclusion criteria.
After enrollment of 160 patients, inclusion criterion was changed from 80 years old to up to 85 years old with >8 ASPECTS.