Long-Term Outcomes of Mechanical Thrombectomy for Stroke: A Meta-Analysis
Table 2
Characteristics of intervention and control arms of included studies.
Trial
IMS III
MR CLEAN
REVASCAT
Total
Intervention Arm
ITT patients, n
434
233
103
770
Stent retrieve device, n (%)
14 (3)
190 (82)
98 (95)
302 (39)
IA-tPA, n (%)
266 (61)
24 (10)
0 (0)
290 (38)
IV-tPA, n (%)
434 (100)
203 (87)
70 (68)
707 (92)
Mean/median NIHSS score
17
17
17
Mean/median ASPECTS
NA
9
7
Mean/median age, y
69
65.8
65.7
LVO, n (%)
190 (44)
233 (100)
103 (100)
526 (68)
GA, n (%)
NR
88 (38)
7 (7)
95 (28)
Mean/median time from onset to groin puncture, min
208
260
269
Median time from onset to randomization, min (IQR)
NR
204 (152-251)
223 (170-312)
Control Arm
ITT patients, n
222
267
103
592
IV-tPA, n (%)
222 (100)
242 (91)
80 (78)
544 (92)
Mean/median NIHSS score
16
18
17
Mean/median ASPECTS
NA
9
8
Mean/median age, y
68
65.7
67.2
LVO, n (%)
92 (41)
267 (100)
103 (100)
462 (78)
Mean/median time to tPA, min
121.2
87
105
Median time from onset to randomization, min (IQR)
NR
196 (149-266)
226 (168-308)
ASPECTS is Alberta Stroke Program Early CT score; GA is general anesthesia; IA is intra-arterial; ITT is intention-to-treat; LVO is large vessel occlusion; NA is not applicable; NR is not reported; tPA is tissue plasminogen activator. After 284 patients had undergone randomization, identification of occlusion with CT angiography could determine trial eligibility for patients with NIHSS score of 8 or 9. Randomization was required within 40 minutes after the initiation of the tPA infusion.
