Modulation of Blood Coagulation and Hematological Parameters by Crassocephalum crepidioides Leaf Methanol Extract and Fractions in STZ-Induced Diabetes in the Rat

Table 1

Coagulation profile of diabetic rats treated with 100 mg/kg body weight of C. crepidioides crude extract and fractions.

Parameters group	BT (minutes)	CT (minutes)	PT (seconds)	aPTT (seconds)
Normal control	2.00 ± 0.11^b	1.58 ± 0.14^d	25.00 ± 2.43^h	31.00 ± 2.92^b
Diabetic control	1.37 ± 0.12^a	1.48 ± 0.12^d	17.00 ± 2.42^g	22.00 ± 0.56^a
Hexane	2.39 ± 0.15^b	3.45 ± 0.15^f	92.00 ± 8.09^k	136.00 ± 9.39^d
Butanol	2.17 ± 0.16^b	2.44 ± 0.10^e	81.00 ± 3.63^k	74.00 ± 9.32^c
Aqueous	4.11 ± 0.50^c	3.48 ± 0.19^f	66.00 ± 6.37^j	126.00 ± 6.96^d
Ethyl acetate	3.58 ± 0.40^c	2.54 ± 0.13^e	74.00 ± 5.53^k	74.00 ± 6.91^c
Methanol	2.29 ± 0.05^b	2.08 ± 0.16^d	47.00 ± 2.46^i	68.00 ± 1.73^c
Metformin	3.50 ± 0.22^c	2.58 ± 0.18^e	68.00 ± 8.77^j	115.00 ± 10.39^d