Modulation of Blood Coagulation and Hematological Parameters by Crassocephalum crepidioides Leaf Methanol Extract and Fractions in STZ-Induced Diabetes in the Rat

Table 2

Hematological parameters of experimental rats treated with varying concentrations of aqueous and hexane fractions.

Parameters	NC	NA	DC	DA	Hex 50	Hex 100	Hex 200	Aq. 50	Aq. 100	Aq. 200	Met
RBC (x 10^12/L)	7.70 ± 0.01^b	7.01 ± 0.66^b	6.44 ± 0.10^a	6.86 ± 0.19^b	7.13 ± 0.12^b	7.36 ± 0.14^b	6.50 ± 0.40^a	6.81 ± 0.08^b	7.22 ± 0.37^b	6.45 ± 0.03^a	7.30 ± 0.13^b
HGB (g/dl)	14.13 ± 0.09^b	13.57 ± 0.67^b	11.20 ± 0.31^c	11.40 ± 0.40^c	13.40 ± 0.23^b	13.73 ± 0.07^b	12.63 ± 0.23^b	12.40 ± 0.29^b	14.20 ± 0.69^b	12.53 ± 0.03^b	13.27 ± 0.19^b
WBC (x10^9/L)	4.00 ± 0.12^a	3.50 ± 0.36^a	9.17 ± 0.61^c	3.50 ± 0.64^a	4.80 ± 0.92^b	4.13 ± 0.07^a	5.47 ± 0.75^b	6.80 ± 0.35^b	6.70 ± 0.92^b	4.77 ± 0.84^b	3.90 ± 0.06^a
PCV (%)	43.17 ± 0.49^h	39.53 ± 2.22^g	32.10 ± 1.13^f	38.60 ± 1.33^g	33.23 ± 6.68^f	42.20 ± 0.23^h	38.13 ± 0.78^g	36.90 ± 0.72^g	39.50 ± 1.16^g	34.90 ± 0.64^g	38.73 ± 0.09^g
PLT (x10^9/L)	518.00 ± 6.25^m	516.33 ± 1.16^m	485.67 ± 22.2^m	333.33 ± 18.49^l	345.67 ± 18.41^l	207.33 ± 4.37^k	337.67 ± 12.02^l	264.33 ± 26.57^k	388.33 ± 18.95^l	265.67 ± 25.53^k	383.67 ± 3.84^l
Ca^2+ (mg/dl)	8.90 ± 0.03^b	8.40 ± 0.03^a	8.70 ± 0.10^b	8.30 ± 0.03^a	8.40 ± 0.03^a	8.90 ± 0.03^b	8.60 ± 0.03^b	8.50 ± 0.03^a	8.40 ± 0.03^a	8.40 ± 0.03^a	8.50 ± 0.03^a

Results are the mean ± SE values of duplicate determinations (n = 4). Mean values followed by different letters are significantly () different while those with the same alphabet within the row are not significantly () different. Keys: RBC: red blood cells, HGB: hemoglobin, WBC: white blood cells, PCV: packed cell volume, PLT: platelet count, NC: normal control, NA: normal aspirin, DC: diabetic control, DA: diabetic aspirin, Hex 50, 100 &200: hexane 50 mg/kg, 100 mg/kg &200 mg/kg, Aq. 50,100 &200: aqueous 50 mg/kg, 100 mg/kg &200 mg/kg, Met: metformin.