Modulation of Blood Coagulation and Hematological Parameters by Crassocephalum crepidioides Leaf Methanol Extract and Fractions in STZ-Induced Diabetes in the Rat

Table 3

Some GC—MS identified bioactive compounds of the hexane fraction of C. crepidioides leaf extract that may be responsible for observed activities.

S/N	Retention time (mins)	Name of compound (library ID)	Molecular formula	Peak area (%)	Reported biological activity
1	3.586	Butyrolactone	C4H6O2	0.98	Antimicrobial.; Central nervous system depressant (CNS) and hypnotic.; Anaesthetic.
2	5.449	Benzene acetaldehyde	C8H8O	1.11	Antioxidant; antibacterial, anaesthetic.
3	5.568	1-methyl, 2-Pyrrolidinone	C5H9NO	2.69	Surfactant, antifungal; antioxidant, antibacterial; anticancer, anticonvulsant.
4	10.286	Benzofuran	C8H6O	1.43	Antidepressant, anticancer, antiviral, antifungal, antioxidant, antipsychotic, anti-inflammatory.
5	13.640	Thujone	C10H16O	0.56	Antiplatelet antibacterial, antifungal, antinociceptive, insecticidal, anthelmintic antioxidant.
6	14.180	Eugenol	C10H12O2	4.43	Anti-inflammatory, antiseptic, antiaggregant.
7	19.795	Benzofuranone	C8H6O	2.99	Antioxidant, anticancer
8	22.151	1,9-octadecadiene	C18H34	0.78	Not stated
9	24.816	Orcinol	C7H8O2	3.14	Antifungal, antimicrobial, and keratolytic.
10	26.704	Hexadecanoic acid, methyl ester	C17H34O2	1.48	Antioxidant, hypocholesterolemic, nematicide, Pesticide, antiandrogenic, flavor, hemolytic, 5-alpha reductase inhibitor.
11	27.250	n-Hexadecanoic acid	C16H32O2	1.19	Antioxidant, anti-inflammation hypocholesterolemic, nematicide Pesticide, Lubricant, antiandrogenic, flavor, hemolytic, 5-alpha reductase inhibitor.
12	28.816	7,10,13-Hexadecatrienoic acid, methyl ester	C20H36O3	5.74	Antibacterial, antifungal.
13	29.404	9,12,15-Octadecatrienoic acid (α-linolenic acid)	C18H30O2	4.52	Anti-inflammatory, Hypolipidemic, antiaggregant, Antileukotriene, antiprostatic, immunostimulant, vasodilator, 5-alpha reductase inhibitor.

Main activity sources: Duke [30, 31].