Mesotherapy: From Historical Notes to Scientific Evidence and Future Prospects

Table 1

Main researchers of mesotherapy.

Karl Baunscheidt	The first drug dermal injection (two millimeters)	1847
Alexander Wood	First injection of dermic morphine	1853
Bartolomeo Guala	Systematic hypodermic treatment in hospital	1860
Gaetano Primavera	First experiment to assess the degree of drug absorption in the urine after hypodermic administration	1867
The London Medical Society	Definition of “hypodermic injections”	1867
Physicians during the Franco-Prussian war	Doctors injected distilled water into the dermis for pain	1870
William Halsted	Intradermal inoculation of sterile water induces local anesthesia	1885
Pietro Orlandini	Dermal punctures for pain	1894
George D Gammon and Isaac Starr	The analgesic effect of sterile water inoculation into the skin for pain	1941
Michel Pistor	Proposed the term “mesotherapy”	1958
Sergio Maggiori	Proposed the term “local intradermal therapy” (LIT)	2004