Environmentally Friendly Methods for Flavonoid Extraction from Plant Material: Impact of Their Operating Conditions on Yield and Antioxidant Properties

Table 4

Experimental conditions for supercritical fluid extraction of flavonoids.

Source	Experimental conditions	Flavonoid	Yield	Reference
Salvia officinalis	Solv: CO2-water; Flow rate: 2 L/min; Temp: 60°C; Time: 10 min; Pressure: 45 MPa	Quercetin 3-glucuronide	1270 ± 89 μg/g	[115]
Morus alba (a) and Morus nigra (b) leaves	Solv: CO2; Flow rate: 0.194 kg/h; Temp: 40°C; Time: 17 h; Pressure: 300 bar	TFC	22.5 ± 0.7 mg/g (a); 43.5 ± 0.1 mg/g (b)	[59]
Odontonema strictum leaves	Solv: CO2-EtOH (85 : 15); Flow rate: 15 g/min; Temp: 65°C; Time: 270 min; Pressure: 200 bar	TFC	230.43 mg/g	[138]
Abelmoschus manihot L. flowers	Solv: CO2-90% EtOH; Flow rate: 2 L/min; Temp: 60°C; Time: 10 min; Pressure: 20 MPa	TFC	41.58 mg/g	[141]
Cissus sicyoides L. leaves and stems	Solv: CO2-EtOH (10%); Flow rate: 4.52 g/min; Temp: 40°C; Time: 3.5 h; Pressure: 400 bar	TFC	12.13 ± 0.29 mg/g	[142]
Spina gleditsiae	Solv: CO2; Flow rate: —; Temp: 48°C; Time: —; Pressure: 40 MPa	TFC	0.793%	[143]

Solv: solvent, Temp: temperature, TFC: total flavonoid content, EtOH: ethanol, and MeOH: methanol.