Evaluation of Antidiabetic Properties of the Leaves Extract of Ficus vallis-choudae Delile in a Model of Type 2 Diabetes Induced by High-Fat Diet and Streptozotocin

Table 4

Effect of AEFV on the parameters of oxidative stress.

Parameters	Organ	Normal control	Diabetic control	Metformin (40 mg/kg)	AEFV
					110 mg/kg	220 mg/kg	440 mg/kg
SOD (U/mg)	Liver	95.23 ± 1.75	30.2 ± 1.83	93.83 ± 6.11^c	91.78 ± 2.08^c	97.19 ± 1.99^c	106.14 ± 5.74^c
	Heart	90.83 ± 2.70	46.91 ± 1.42	89.88 ± 3.13^c	88.32 ± 1.55^c	88.32 ± 2.51^c	101.45 ± 3.23^c
	Kidney	80.91 ± 2.70	61.21 ± 1.37	72.99 ± 1.40^a	74.12 ± 4.30^a	80.33 ± 1.45^c	86.34 ± 2.41^c
CAT (µmol/mg)	Liver	57.40 ± 3.28	23.10 ± 1.27	59.57 ± 1.49^c	55.27 ± 1.53^c	60.97 ± 3.05^c	72.17 ± 1.26^c
	Heart	34.78 ± 2.28	15.75 ± 0.76	34.26 ± 1.07^c	37.95 ± 0.76^c	39.13 ± 1.00^c	42.32 ± 1.36^c
	Kidney	59.88 ± 1.91	29.71 ± 1.52	56.92 ± 1.20^c	65.76 ± 2.10^c	70.01 ± 4.51^c	70.82 ± 0.65^c
GSH (nmol/g)	Liver	6.73 ± 0.97	2.57 ± 0.37	5.31 ± 0.66^a	3.76 ± 0.39	5.50 ± 0.36^a	6.60 ± 0.34^b
	Heart	6.30 ± 0.44	2.30 ± 0.37	5.41 ± 0.24^c	4.35 ± 0.45^a	5.63 ± 0.47^c	6.30 ± 0.38^c
	Kidney	5.49 ± 0.54	2.30 ± 0.36	4.45 ± 0.74	2.38 ± 0.32	4.49 ± 0.50	4.56 ± 0.35^a
MDA (nmol/g)	Liver	31.48 ± 1.19	94.02 ± 1.38	24.19 ± 1.22^c	34.01 ± 1.82^c	43.53 ± 1.32^c	21.39 ± 0.91^c
	Heart	29.14 ± 1.38	58.74 ± 1.29	31.34 ± 1.68^c	40.31 ± 2.25^c	31.91 ± 2.16^c	30.40 ± 1.29^c
	Kidney	40.21 ± 1.35	69.87 ± 0.56	31.90 ± 0.92^c	41.24 ± 1.75^c	30.23 ± 1.57^c	27.98 ± 0.88^c

All results were expressed as mean ± standard derivation (n = 5). Data analysis was performed by one-way ANOVA followed by Turkey’s post hoc test. statistically significant compared with the normal control group. , , statistically significant compared with the untreated diabetic control. AEFV: aqueous extract of the leaves of Ficus vallis-choudae; SOD: superoxide dismutase; CAT: catalase; GSH: reduced glutathione; MDA: malondialdehyde.