Predicting the Most Deleterious Missense Nonsynonymous Single-Nucleotide Polymorphisms of Hennekam Syndrome-Causing CCBE1 Gene, In Silico Analysis

Table 5

iStable 2.0 result for prediction of CCBE1 protein stability due to the selected nsSNPs in CCBE1.

AAS	Confidence score	Stability
G330E	−0.002680719	Increase
C174R	0.021838337	Increase
C102S	−1.2213084	Decrease
G107D	−0.86388123	Decrease
R125W	−0.85255766	Decrease
G327R	0.0042461157	Increase
P290L	0.2298831	Increase
K355T	−0.052274585	Decrease
Q353R	0.8725257	Increase
D336N	−1.2082165	Decrease
T153N	−0.546193	Decrease
C75S	−1.0542232	Decrease
P87S	−1.9976869	Decrease
T144M	0.23297998	Increase
R118L	−0.5704589	Decrease
D397Y	0.071232796	Increase
R301W	−0.3441298	Decrease
P249S	−1.1325055	Decrease
D41E	0.4703572	Increase
S19N	0.77003396	Increase
R167W	−0.4350294	Decrease
A96G	−0.041893244	Increase