An Update of Research Animal Models of Inflammatory Bowel Disease

Figure 1

Colitis induction in SCID mice. Experimentally, the adoptive T-cell transfer model induces chronic small bowel and colonic inflammation, which resembles some key aspects of human IBD. To generate the model, CD4⁺CD45RB^high T-cells (which are CD25^–) are sorted and isolated from donor BALB/c splenocytes. Cell transfer to a syngeneic immunodeficient SCID or RAG2^–/– recipient generates a model with primary inflammation in the colon.