Physicochemical Stability Study of Oral Suspension Containing Ruxolitinib in Children with Steroid-Refractory Acute Graft-Versus-Host Disease

Table 1

Remaining concentration of ruxolitinib phosphate and retention time of degradation products detected.

Stress condition	% remaining			Retention time of degradation peak (min)
	T2 h	T6 h	T24 h
Acidic (1M HCl, 60°C)	100.9	100.4	100.6
Alkaline (1M NaOH, 60°C)	41.9	36.2	29.9	2.8; 3.4; 3.9
Oxidative (3% H2O2, 60°C)	98.2	90.5	6.0	2.8; 3.4; 4.3; 4.8