Acute and Subacute Toxicity Assessment of Andrographolide-2-hydroxypropyl-β-cyclodextrin Complex via Oral and Inhalation Route of Administration in Sprague-Dawley Rats

Figure 2

Photomicrographs of the liver, kidney and lungs of male and female rats in subacute inhalation toxicity of AND-2-HyP-β-CYD complex: (a) normal control, (b) vehicle control (citrate buffer, pH 6.5), (c) low dose (0.5 mg/L/4 h), (d) medium dose (1 mg/L/4 h), and (e) high dose (1.66 mg/L/4 h). Magnification of 40x was used. Black arrow indicates the presence of inflammation in the lungs, liver, and kidney of both the sexes at low, medium, and high doses. Yellow arrow denotes the degenerative changes in the kidney of medium and highest doses. Red arrows in the lungs of male rats at mid and high doses show sign of decongestion, whereas blue arrows in the lungs of female rats at low and high doses reveal degenerative changes in perialveolar tissues.