Acute and Subacute Toxicity Assessment of Andrographolide-2-hydroxypropyl-β-cyclodextrin Complex via Oral and Inhalation Route of Administration in Sprague-Dawley Rats
Table 2
Evaluation of biochemical parameters in the repeated oral dose subacute toxicity study of AND-2-HyP-β-CYD complex.
Groups
Parameters
Normal control
Low dose (200 mg/kg)
Moderate dose (400 mg/kg)
High dose (666 mg/kg)
Reversal control
Reversal control of high dose (666 mg/kg)
Male
ALB (g/dL)
3.84 ± 0.19
3.40 ± 0.36
3.81 ± 0.39
3.99 ± 0.14
3.72 ± 0.16
3.70 ± 0.19
ALP (IU/L)
121.0 ± 15.13
106.33 ± 3.45
102.83 ± 4.96
104.67 ± 4.39
106.67 ± 4.27
107.83 ± 7.04
ALT (U/L)
37.62 ± 4.03
40.67 ± 3.96
33.50 ± 3.07
41.83 ± 2.88
39.67 ± 3.40
44.67 ± 4.36
AST (U/L)
91.50 ± 3.71
99.67 ± 8.52
109.17 ± 17.51
133.0 ± 6.78
109.0 ± 10.73
109.33 ± 9.01
BIL (U/L)
0.10 ± 0.00
0.10 ± 0.00
0.10 ± 0.00
0.10 ± 0.00
0.10 ± 0.00
0.10 ± 0.00
CA (mg/dL)
9.80 ± 0.33
8.02 ± 1.37
9.52 ± 0.23
10.28 ± 0.18
9.33 ± 0.15
9.37 ± 0.37
CHO (mg/dL)
46.0 ± 4.23
42.83 ± 3.75
46.67 ± 2.82
43.17 ± 2.24
49.83 ± 2.33
46.00 ± 4.07
CREJ (mg/dL)
0.26 ± 0.02
0.26 ± 0.02
0.35 ± 0.03
0.28 ± 0.03
0.38 ± 0.03
0.32 ± 0.03
PHOS (mg/dL)
7.0 ± 0.56
7.65 ± 0.56
7.47 ± 0.57
8.53 ± 0.59
7.97 ± 0.50
8.00 ± 0.62
TP (g/dL)
6.25 ± 0.30
6.72 ± 0.21
6.28 ± 0.26
6.02 ± 0.29
6.52 ± 0.25
6.05 ± 0.24
UREA (mg/dL)
18.17 ± 0.48
17.0 ± 1.03
15.83 ± 1.11
16.67 ± 0.80
16.00 ± 0.82
16.50 ± 1.34
GLU (mg/dL)
128.33 ± 3.69
128.17 ± 4.83
122.67 ± 3.90
129.0 ± 3.50
129.50 ± 4.49
141.67 ± 5.08
Female
ALB (g/dL)
4.02 ± 0.23
3.87 ± 0.31
3.94 ± 0.22
3.87 ± 0.27
3.92 ± 0.16
3.73 ± 0.26
ALP (U/L)
98.50 ± 5.19
100.67 ± 6.29
103.0 ± 6.29
100.83 ± 6.37
97.0 ± 6.69
153.40 ± 17.38
ALT (U/L)
43.50 ± 3.89
45.83 ± 2.57
39.33 ± 3.94
38.0 ± 3.69
43.33 ± 4.39
41.83 ± 3.85
AST (U/L)
90.17 ± 9.92
93.0 ± 3.79
127.83 ± 10.22
131.0 ± 6.50
98.17 ± 10.46
129.60 ± 16.10
BIL (U/L)
0.10 ± 0.00
0.10 ± 0.00
0.10 ± 0.00
0.10 ± 0.00
0.10 ± 0.00
0.10 ± 0.00
CA (mg/dL)
8.85 ± 0.37
9.67 ± 0.17
9.72 ± 0.10
9.45 ± 0.27
8.79 ± 0.31
8.72 ± 0.20
CHO (mg/dL)
43.0 ± 2.68
54.33 ± 3.73
43.17 ± 2.86
50.83 ± 2.21
48.0 ± 3.09
41.60 ± 1.97
CREJ (mg/dL)
0.30 ± 0.03
0.30 ± 0.03
0.39 ± 0.04
0.31 ± 0.03
0.21 ± 0.04
0.31 ± 0.03
PHOS (mg/dL)
8.55 ± 0.39
7.83 ± 0.54
7.73 ± 0.72
7.18 ± 0.46
8.05 ± 0.43
8.06 ± 0.80
TP (g/dL)
6.80 ± 0.16
6.03 ± 0.27
6.25 ± 0.35
6.37 ± 0.25
5.90 ± 0.32
5.86 ± 0.26
UREA (mg/dL)
16.50 ± 0.96
16.50 ± 0.99
15.0 ± 0.89
19.67 ± 1.09
17.33 ± 0.99
23.0 ± 1.04
GLU (mg/dL)
130.83 ± 6.26
118.17 ± 4.36
114.17 ± 5.49
134.33 ± 7.74
136.50 ± 4.33
129.0 ± 5.02
Each value represents the mean ± standard deviation (n = 6). One-way ANOVA test () followed by Dunnett’s test. , one-way ANOVA test with Dunnett’s test.
