Acute and Subacute Toxicity Assessment of Andrographolide-2-hydroxypropyl-β-cyclodextrin Complex via Oral and Inhalation Route of Administration in Sprague-Dawley Rats
Table 3
Evaluation of hematological parameters in the inhalation subacute toxicity study of AND-2-HyP-β-CYD complex.
Groups
Parameters
Normal control
Vehicle control
Low dose
Mid dose
High dose
Male
WBCB (×103 cells/μL)
6.18 ± 3.03
7.41 ± 4.24
13.32 ± 2.54
7.44 ± 3.2
8.19 ± 4.47
RBC (×106 cells/μL)
5.80 ± 2.16
8.76 ± 1.94
8.24 ± 0.41
8.19 ± 0.63
8.16 ± 1.17
Mean HGB (g/dL)
11.67 ± 3.44
15.67 ± 2.73
14.8 ± 0.85
15.05 ± 0.45
15.1 ± 1.40
HCT (%)
47.5 ± 10.47
52.75 ± 10.21
47.6 ± 2.19
49.75 ± 1.7
48 ± 7.41
MCV (fL)
86.0 ± 14.49
61.0 ± 2.44
57.6 ± 1.51
61 ± 3.16
59 ± 2.91
MCH (pg)
20.0 ± 1.82
17.75 ± 0.95
17.6 ± 0.54
18.25 ± 0.95
18.2 ± 1.09
MCHC (g/dL)
23.5 ± 2.38
29.25 ± 1.25
30.8 ± 0.83
30 ± 0.00
31 ± 2.91
PLT (×103 cells/μL)
637.75 ± 84.26
440.5 ± 122.56
568.2 ± 18.72
444.5 ± 109.36
466.6 ± 208.42
NEUT (%)
16.75 ± 4.78
15.5 ± 8.06
15 ± 3.67
16.25 ± 4.5
15.2 ± 2.58
LYM (%)
61 ± 10.78
69.5 ± 7.89
69.6 ± 9.28
64 ± 6.05
71.4 ± 1.81
MONO (%)
15.5 ± 6.55
9.25 ± 4.57
7.8 ± 6.26
12.25 ± 6.13
7.4 ± 3.04
EOS (%)
1.0 ± 0.00
1.75 ± 0.95
1.6 ± 0.54
2.75 ± 0.95
1.2 ± 0.44
BASO (%)
5.75 ± 1.70
4.0 ± 1.15
6.0 ± 1.87
4.75 ± 1.25
5.2 ± 1.78
Female
WBCB (×103 cells/μL)
5.74 ± 1.83
7.43 ± 1.00
6.82 ± 1.26
6.64 ± 2.10
6.57 ± 1.20
RBC (×106 cells/μL)
8.0 ± 0.44
7.91 ± 0.20
8.0 ± 1.59
8.1 ± 0.42
8.2 ± 0.37
Mean HGB (g/dL)
14.35 ± 0.75
14.4 ± 0.47
14.88 ± 2.3
14.44 ± 0.75
14.58 ± 0.78
HCT (%)
49.0 ± 3.57
49.66 ± 1.63
47.83 ± 9.57
47.8 ± 2.16
48.6 ± 2.50
MCV (fL)
60.83 ± 1.83
62.66 ± 1.03
59.66 ± 2.73
59.0 ± 2.00
58.8 ± 0.83
MCH (pg)
17.5 ± 0.54
17.83 ± 0.40
18.5 ± 1.22
17.4 ± 0.54
17.0 ± 0.00
MCHC (g/dL)
28.66 ± 0.51
28.0 ± 0.00
31.0 ± 2.0
29.8 ± 0.44
29.2 ± 0.44
PLT (×103 cells/μL)
679 ± 125.95
767.16 ± 49.83
684.16 ± 71.19
768.8 ± 109.26
822.4 ± 231.08
NEUT (%)
17.16 ± 2.85
21.0 ± 5.25
17.33 ± 6.91
12.6 ± 8.29
17.6 ± 5.12
LYM (%)
67.0 ± 6.606
66.0 ± 7.29
72.66 ± 8.64
73.4 ± 9.23
71.0 ± 4.47
MONO (%)
8.16 ± 3.81
7.0 ± 2.52
7.0 ± 2.60
10.2 ± 0.54
7.4 ± 4.15
EOS (%)
1.5 ± 0.54
1.0 ± 0.00
1.0 ± 0.00
1.6 ± 0.54
1.0 ± 0.00
BASO (%)
6.33 ± 2.5
5.16 ± 1.72
2.0 ± 0.63
2.2 ± 0.83
3.0 ± 0.70
Each value represents the mean ± standard deviation (n = 6). One-way ANOVA test () followed by Dunnett’s test.
