Research Article
The Association of Obesity and the Antiaging Humoral Factor Klotho in Middle-Aged and Older Adults
Table 1
Characteristics of participants and serum soluble klotho levels.
| | % | Klotho levels (pg/ml) | value |
| Age (years) | | | <0.0001 | 40–59 | 55.4 | 804.3 | | ≥60 | 44.6 | 757.4 | |
| Sex | | | <0.05 | Men | 47.9 | 765.0 | | Women | 52.1 | 796.3 | |
| Race/ethnicity | | | <0.05 | Mexican-American | 6.9 | 804.3 | | Other Hispanic | 4.9 | 828.8 | | NHW | 72.1 | 772.8 | | NHB | 8.6 | 820.6 | | Multiracial | 7.5 | 812.4 | |
| Education | | | <0.001 | ≤11th grade | 12.9 | 796.3 | | High school graduate | 20.8 | 742.5 | | Some college | 32.2 | 772.8 | | College graduate | 34.1 | 804.3 | |
| BMI (kg/m2) | | | <0.0001 | Normal weight | 23.8 | 820.6 | | Overweight | 34.4 | 765.1 | | Obese | 41.8 | 772.8 | |
| Abdominal obesity in men | | | 0.939 | Yes | 55.8 | 765.0 | | No | 44.2 | 765.0 | |
| Abdominal obesity in women | | | <0.0001 | Yes | 75.7 | 780.5 | | No | 24.3 | 862.6 | |
| BMI 25 years to BMI baseline | | | <0.05 | Never obese | 56.8 | 788.3 | | Obese to nonobese | 1.4 | 788.3 | | Nonobese to obese | 33.6 | 765.0 | | Always obese | 8.2 | 804.3 | |
| BMI 10 years prior to BMI baseline | | | <0.05 | Never obese | 52.3 | 796.3 | | Obese to nonobese | 5.9 | 765.0 | | Nonobese to obese | 16.9 | 765.0 | | Always obese | 24.9 | 780.5 | |
| Smoking status | | | <0.0001 | Never | 52.9 | 804.3 | | Former | 29.8 | 772.7 | | Current | 17.3 | 742.4 | |
| Alcohol use | | | <0.0001 | Yes | 78.3 | 772.7 | | No | 21.7 | 812.4 | |
| Physical activity | | | 0.499 | Yes | 33.2 | 834.4 | | No | 66.8 | 826.1 | |
| Diabetes | | | 0.597 | Yes | 16.6 | 828.9 | | No | 83.4 | 828.7 | |
| eGFR (ml/min) | | | <0.0001 | <60 | 10.8 | 736.7 | | ≥60 | 89.2 | 839.8 | |
| 25(OH)D (nmol/L) | | | 0.835 | <50 | 17.9 | 829.6 | | ≥50 | 82.1 | 828.5 | |
|
|
NHW : Non-Hispanic white; NHB: mon-Hispanic black; BMI: body mass index, eGFR: estimated glomerular filtration rate.
|