The Association of Obesity and the Antiaging Humoral Factor Klotho in Middle-Aged and Older Adults

Table 2

Weight change pattern and serum soluble klotho levels (pg/ml) in men and women aged 40–79 years.

	Never obese (ref)	Obese to nonobese	Nonobese to obese	Always obese
Men
BMI 10 years prior to baseline BMI
Model 1	765.0	742.4	757.4	780.5
Model 2	765.0	742.4	765.0	780.5
Model 3	765.0	735.0	765.0	772.7
BMI age 25 years to baseline BMI
Model 1	765.0	749.9	765.0	796.3
Model 2	765.0	757.4	765.0	788.3
Model 3	765.0	765.0	765.0	772.7
Women
BMI 10 years prior to baseline BMI
Model 1	820.5	812.4	765.0	788.3
Model 2	820.5	820.5	757.4	780.5
Model 3	820.5	828.8	757.4	780.5
BMI age 25 years to baseline BMI
Model 1	820.5	871.3	772.7	796.3
Model 2	820.5	897.8	765.0	796.3
Model 3	820.5	888.9	765.0	796.3

compared with the reference category never obese. Model 1: adjusted for age- and gender, model 2: adjusted for model 1 and race/ethnicity, education, smoking, alcohol use, and physical activity, and model 3: adjusted for model 2 and diabetes, eGFR, and 25 (OH)D levels.