Alpha-Mangostin-Loaded Transferrin-Conjugated Lipid-Polymer Hybrid Nanoparticles: Development and Characterization for Tumor-Targeted Delivery

Table 2

Antiproliferative activity of α-mangostin entrapped in Tf-LPHN and Ctrl-LPHN formulations, or free in solution, expressed as IC₅₀ values, in MCF-7, A549, and B16–F10 cell lines, following 48 h treatment (control: blank LPHN) (n = 4) (n.d.: not determined) (vs. α-mangostin solution).

Cell lines	Antiproliferative activity (IC50: µg/mL)
	Tf-LPHN	Ctrl-LPHN	α-Mangostin solution	Blank LPHN
MCF-7	4.16 ± 0.04	5.27 ± 0.05	5.82 ± 0.06	n.d.
A549	4.54 ± 0.18	5.76 ± 0.05	7.70 ± 0.17	n.d.
B16–F10	2.96 ± 0.13	4.30 ± 0.07	7.54 ± 0.09	n.d.