Research Article
Formulation of Ebastine Fast-Disintegrating Tablet Using Coprocessed Superdisintegrants and Evaluation of Quality Control Parameters
Table 1
Composition of various batches of fast disintegrating tablets of ebastine designed by Minitab software.
| | | EBS (mg) | MS (mg) | CPV (mg) | SSG (mg) | CPS (mg) | Talc (mg) | Mannitol (mg) | APM (mg) | MCC112 (mg) | MgS (mg) |
| | B1 | 20 | 69.924 | 5.425 | 15.57 | 6.58 | 3 | 45 | 10 | 23 | 1.5 | | B2 | 20 | 71.892 | 5.425 | 7.75 | 12.432 | 3 | 45 | 10 | 23 | 1.5 | | B3 | 20 | 74.25 | 7.75 | 12.4 | 3.1 | 3 | 45 | 10 | 23 | 1.5 | | B4 | 20 | 85.565 | 5.425 | 0.07 | 6.58 | 3 | 45 | 10 | 23 | 1.5 | | B5 | 20 | 78.9 | 3.1 | 12.4 | 3.1 | 3 | 45 | 10 | 23 | 1.5 | | B6 | 20 | 67.9 | 7.75 | 12.4 | 10.06 | 3 | 45 | 10 | 23 | 1.5 | | B7 | 20 | 81.24 | 3.1 | 3.1 | 6.58 | 3 | 45 | 10 | 23 | 1.5 | | B8 | 20 | 77.745 | 5.425 | 7.75 | 6.58 | 3 | 45 | 10 | 23 | 1.5 | | B9 | 20 | 88.2 | 3.1 | 3.1 | 3.1 | 3 | 45 | 10 | 23 | 1.5 | | B10 | 20 | 81.655 | 1.514 | 7.75 | 6.58 | 3 | 45 | 10 | 23 | 1.5 | | B11 | 20 | 76.59 | 7.75 | 3.1 | 6.58 | 3 | 45 | 10 | 23 | 1.5 | | B12 | 20 | 83.55 | 7.75 | 3.1 | 10.06 | 3 | 45 | 10 | 23 | 1.5 | | B13 | 20 | 73.834 | 9.335 | 7.75 | 6.58 | 3 | 45 | 10 | 23 | 1.5 | | B14 | 20 | 83.597 | 5.425 | 7.75 | 0.727 | 3 | 45 | 10 | 23 | 1.5 | | B15 | 20 | 71.94 | 3.1 | 12.4 | 10.06 | 3 | 45 | 10 | 23 | 1.5 |
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(EBS: ebastine, MS: maize starch, CPV: crospovidone, SSG: sodium starch glycolate, CPS: coprocessed superdisintegrant, MCC112: microcrystalline cellulose 112, Mgs: magnesium stearate, and APM: aspartame).
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