Formulation of Ebastine Fast-Disintegrating Tablet Using Coprocessed Superdisintegrants and Evaluation of Quality Control Parameters

Table 5

Evaluation of precompression parameters of granules of fifteen different trial batches.

Formulations	Bulk density (g.mL^−1)	Tapped density (g.mL^−1)	Carr’s index (%)	Hausner’s ratio	Angle of repose (θ)
B1	0.53 ± 0.008	0.663 ± 0.014	20.13 ± 0.18	1.25 ± 0.003	33.43 ± 0.25
B2	0.496 ± 0.004	0.653 ± 0.005	24.07 ± 0.19	1.31 ± 0.003	36.70 ± 0.28
B3	0.487 ± 0.002	0.647 ± 0.001	24.70 ± 0.43	1.32 ± 0.007	35.90 ± 0.20
B4	0.491 ± 0.002	0.655 ± 0.005	24.93 ± 0.22	1.33 ± 0.004	33.06 ± 0.77
B5	0.494 ± 0.004	0.638 ± 0.006	22.46 ± 0.74	1.29 ± 0.012	31.53 ± 0.32
B6	0.483 ± 0.002	0.641 ± 0.008	24.64 ± 0.48	1.33 ± 0.008	34.26 ± 0.90
B7	0.481 ± 0.002	0.637 ± 0.005	24.42 ± 0.43	1.32 ± 0.007	31.43 ± 1.05
B8	0.442 ± 0.006	0.548 ± 0.002	19.34 ± 1.57	1.24 ± 0.024	33.77 ± 0.63
B9	0.443 ± 0.005	0.555 ± 0.003	20.27 ± 1.46	1.25 ± 0.022	32.97 ± 0.44
B10	0.46 ± 0.021	0.579 ± 0.002	20.63 ± 1.77	1.26 ± 0.03	33.54 ± 0.59
B11	0.486 ± 0.02	0.590 ± 0.002	18.06 ± 0.41	1.22 ± 0.002	27.9 ± 0.3
B12	0.477 ± 0.004	0.596 ± 0.006	19.98 ± 1.80	1.25 ± 0.028	27.73 ± 0.7
B13	0.478 ± 0.005	0.647 ± 0.005	26.11 ± 1.58	1.35 ± 0.029	33.96 ± 0.17
B14	0.586 ± 0.003	0.613 ± 0.001	20.58 ± 1.14	1.26 ± 0.018	32.71 ± 0.75
B15	0.494 ± 0.003	0.654 ± 0.002	24.45 ± 0.80	1.32 ± 0.014	31.83 ± 0.40