Giamila Fantuzzi

Cytokines: Pulling the Body Together as a Whole

recent report after lps stimul il37 transloc nucleus reduc express proinflammatori cytokin the aim studi investig whether transient express il37 mice reduc inflamm concanavalin cona induc hepat lpsinduc sepsi transgen il37 express detect liver lysat mice inject il37 plasmiddna after hydrodynam tail vein inject all mice develop sever acut hepat after cona inject differ histolog score serum alt observ between two group might explain patchi express il37 protein liver howev 2 hrs after cona inject serum level il1 il6 il5 il9 were signific reduc il37express mice seen lps model conclus vivo express human il37 mice reduc local system inflamm conainduc hepat lps challeng

Ana-Maria Bulau

Michaela Fink

Christof Maucksch

Roland Kappler

Doris Mayr

Kai Wagner

Philip Bufler

In Vivo Expression of Interleukin-37 Reduces Local and Systemic Inflammation in Concanavalin A-Induced Hepatitis

hepcidin main regul system iron homeostasi primarili produc liver also express mrnalevel peripheri tissu includ subcutan viscer adipos tissu obesiti associ elev hepcidin concentr iron deplet suggest exagger fat mass obes could contribut signific circul hepcidin level consequ alter iron homeostasi the object studi determin abdomin subcutan adipos tissu abscat releas hepcidin vivo releas modifi obes arterioven differ concentr hepcidin were measur across abscat 9 obes 9 lean adult overal mean plasma hepcidin concentr were signific higher arteri compar abscat venous sampl mean differ arterializedabscat venous plasma hepcidin net region releas calcul becaus mean venous plasma hepcidin concentr were lower than mean arteri concentr indic net releas signific correl between abscat venous arteri plasma hepcidin concentr anthropometr variabl were observ find from vein drainag studi suggest net releas hepcidin from abscat depot therebi abil signal system even obes

Lisa Tussing-Humphreys

Keith N. Frayn

Steven R. Smith

Mark Westerman

A. Louise Dennis

Elizabeta Nemeth

Jessica Thomson

Cenk Pusatcioglu

Subcutaneous Adipose Tissue from Obese and Lean Adults Does Not Release Hepcidin In Vivo

the clone leptin 1994 zhang introduc novel concept about white adipos tissu wat veri dynam organ releas plethora immun inflammatori mediat adipokin cytokin which involv multipl diseas actualli adipokin exert potent modulatori action target tissu involv rheumat diseas includ cartilag synovi bone immun cell the goal paper elucid recent find concern involv adipokin rheumat diseas rheumatoid arthriti osteoarthr system lupus erythematosus sle

Morena Scotece

Javier Conde

Rodolfo Gómez

Veronica López

Francisca Lago

Juan Jesus Gómez-Reino

Oreste Gualillo

Beyond Fat Mass: Exploring the Role of Adipokines in Rheumatic Diseases

the inflammasom import innat immun pathway regul least two host respons protect against infect 1 secret proinflammatori cytokin il1 il18 2 induct pyroptosi form cell death inflammasom which differ type have been identifi multiprotein complex contain pattern recognit receptor belong nodlik receptor famili pyhin famili proteas caspase1 the molecular aspect involv activ differ inflammasom various pathogen be rapid elucid role dure infect be character product il1 il18 induct pyroptosi infect cell have been shown protect against mani infecti agent here review recent literatur concern inflammasom activ context bacteri infect identifi import question answer futur

Manoranjan Sahoo

Ivonne Ceballos-Olvera

Laura del Barrio

Fabio Re

Role of the Inflammasome, IL-1<svg style="vertical-align:-3.294pt;width:12.6375px;" id="M1" height="19.200001" version="1.1" viewBox="0 0 12.6375 19.200001" width="12.6375" xmlns="http://www.w3.org/2000/svg">
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obes type 2 diabet effici skelet muscl repair follow injuri may requir onli restor muscl structur function also maintain exercis capac insulin sensit the hypothesi studi muscl regener would impair mice which common mous model obes type 2 diabet muscl injuri produc cardiotoxin inject regener assess morpholog immunostain techniqu muscl regener delay mice less sever model insulin resist feed highfat diet wildtyp mice angiogenesi cell prolifer myoblast accumul were also impair mice highfat diet mice the impair muscl regener were associ impair macrophag accumul macrophag have been shown previous requir effici muscl regener impair regener mice could due part lack leptin signal sinc leptin express both damag muscl cultur muscl cell summari impair muscl regener mice associ reduc macrophag accumul angiogenesi myoblast activ could have implic insulin sensit skelet muscl obes type 2 diabet patient

Mai-Huong Nguyen

Ming Cheng

Timothy J. Koh

Impaired Muscle Regeneration in Ob/ob and Db/db Mice

inflammasom intracellular multiprotein complex coordin matur interleukin il18 respons pathogen metabol danger both cytokin have been link intestin inflamm howev recent evolv concept ascrib major role inflammasom maintain intestin homeostasi this review recapitul it posit develop inflammatori bowel diseas therebi outlin model which hypo well hyperfunct can lead imbal system depend specif cell popul affect epithelium inflammasom essenti regul permeabl epitheli regener through sens commens microb while excess inflammasom activ within lamina propria contribut sever intestin inflamm

Donata Lissner

Britta Siegmund

The Multifaceted Role of the Inflammasome in Inflammatory Bowel Diseases

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The Scientific World Journal

Cytokines & Chemokines

Cytokines & Chemokines

Articles

Cytokines: Pulling the Body Together as a Whole

In Vivo Expression of Interleukin-37 Reduces Local and Systemic Inflammation in Concanavalin A-Induced Hepatitis

Subcutaneous Adipose Tissue from Obese and Lean Adults Does Not Release Hepcidin In Vivo

Beyond Fat Mass: Exploring the Role of Adipokines in Rheumatic Diseases

Role of the Inflammasome, IL-1, and IL-18 in Bacterial Infections

Impaired Muscle Regeneration in Ob/ob and Db/db Mice

The Multifaceted Role of the Inflammasome in Inflammatory Bowel Diseases

The Scientific World Journal

Cytokines & Chemokines

Cytokines & Chemokines

Articles

Cytokines: Pulling the Body Together as a Whole

In Vivo Expression of Interleukin-37 Reduces Local and Systemic Inflammation in Concanavalin A-Induced Hepatitis

Subcutaneous Adipose Tissue from Obese and Lean Adults Does Not Release Hepcidin In Vivo

Beyond Fat Mass: Exploring the Role of Adipokines in Rheumatic Diseases

Role of the Inflammasome, IL-1 𝛽 , and IL-18 in Bacterial Infections

Impaired Muscle Regeneration in Ob/ob and Db/db Mice

The Multifaceted Role of the Inflammasome in Inflammatory Bowel Diseases

Role of the Inflammasome, IL-1, and IL-18 in Bacterial Infections