The advent application of nanotechnology, or in a broad way nanostrategies, for efficacious and efficient delivery and disposition of bioactives is presently being proposed in various therapeutic interventions. Nanomedicine is now firmly established to be an important part of the so-called “integrated drug-discovery-delivery process.” Nanoscaling of the drug per se or of the delivery system assists in overcoming not only the biopharmaceutical barriers but it may also additionally contribute towards the overwhelming biological barriers and pathways which in turn may govern the eventual pharmacokinetic, pharmacodynamic, and metabolism issues making nanostrategies at biointerfaces– a stimulating field that attracts the attention of the researchers.

To overpower the interfaces at biological, cellular, microbial, and immunological barriers, nanoscale drug delivery strategies can be empowered by functionalization of these constructs with specialized moieties capable of site-specific delivery and tailored release generating robust and efficacious nanotherapeutic modalities. In this special issue, we invite experts as well as emerging scientists to submit original research and review articles that highlight innovative and rationally designed nanostrategies capable of interacting with the biointerfaces, representing numerous biological barriers, through the augmentation and modification of the nanocentered delivery systems. Potential topics include, but are not limited to:

• Nanoscale biological interactions of nanomaterials at nanobiointerface
• Microscopic analysis and computational modeling of nanocarriers with respect to biological membranes
• Improved delivery of biotherapeutic agents through chemical and ligand functionalization
• Nanoplatforms for bioactive delivery in therapeutic interventions involving skin, mucosal, and blood-brain barriers
• Advanced nanomaterials and nanoconjugates fabricated using environmentally responsive polymers
• Application of nanoparticles to drug discovery and biology
• Protein- and peptide-enabled nanosystems
• De novo design of nanostructured materials capable of biophysical translation

Before submission authors should carefully read over the journal’s Author Guidelines, which are located at http://www.hindawi.com/journals/tswj/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/submit/journals/tswj/pharmaceutics/bioint/ according to the following timetable: