selenium known possess both genotox antigenotox properti present studi have evalu genotox antigenotox three selenium compound sodium selen sodium selenit selen acid measur vitro micronucleus induct assay were conduct whole blood lymphocyt tk6 lymphoblastoid cell line without cotreat potassium dichrom known genotox compound general compound were more activ tk6 cell than were blood lymphocyt onli 1 selen acid increas frequenc binucl cell contain micronuclei bnmn blood lymphocyt while all three selenium compound increas bnmn tk6 cell addit combin selen acid potassium dichrom result lower frequenc bnmn than potassium dichrom alon blood lymphocyt while combin sodium selen potassium dichrom produc lower frequenc bnmn than potassium dichrom alon tk6 cell the concentr selenium compound were use combin medium compon biolog physiolog whole blood lymphocyt tk6 cell could have affect redox potenti compound switch chemic from prooxid antioxid status viceversa the lower activ compound blood lymphocyt may due protect effect blood compon the result indic genotox antigenotox properti selenium compound high depend upon condit under which evalu

Eduard Cemeli

Ricard Marcos

Diana Anderson

Genotoxic and antigenotoxic properties of selenium compounds in the in vitro micronucleus assay with human whole blood lymphocytes and tk6 lymphoblastoid cells

Demetrios P. Matthopoulos

Evaluating Side Effects of Human Exposure to Noxious Agents

nowaday constant increas concern regard mutagen carcinogen potenti varieti harm environment factor which human expos natur anthropogen environ these factor exert hazard potenti human person diet smoke pharmaceut cosmet occup environ constitut part anthropogen environ well known genet damag due factor has dramat implic human health sinc most environment genotox factor induc arrest delay cell cycl progress convent analysi chromosom metaphas may underestim genotox potenti prematur chromosom condens pcc induc either mean cell fusion specif chemic enabl microscop visual interphas chromosom whose morpholog depend cell cycl stage well analysi structur numer aberr phase cell cycl the pcc has been success use problem involv cell cycl analysi diagnosi prognosi human leukaemia assess interphas chromosom malform result from exposur radiat chemic well elucid mechan under convers dna damag chromosom damag report particular emphasi given advantag pcc methodolog use altern convent metaphas analysi answer question field radiobiolog biolog dosimetri toxicogenet clinic cytogenet experiment therapeut

Vasiliki I. Hatzi

Georgia I. Terzoudi

Christina Paraskevopoulou

Vasilios Makropoulos

Gabriel E. Pantelias

The use of premature chromosome condensation to study in interphase cells the influence of environmental factors on human genetic material

pesticid known contain numer genotox compound howev genotox biomonitor studi worker occup expos pesticid have produc variabl result studi employ comet assay examin dna damag peripher blood lymphocyt pbls from 64 greenhous worker from almería southeastern spain comparison pbls from 50 men from same area engag ani agricultur work the result indic were differ basal level dna damag two studi group addit exposur pbl from worker control hydrogen peroxid γirradi led similar level dna damag subsequ repair induc dna damag also similar both studi popul smoke had impact ani respons the result studi indic greenhous worker had detect increas dna damag alter cellular respons dna damag compar our control popul

Stylianos M. Piperakis

Konstantina Kontogianni

Michael M. Piperakis

Ricardo Marcos

Smaragdi Tsilimigaki

Effects of Pesticides on Occupationally Exposed Humans

petroleum one main energi sourc worldwid its transport perform big tanker follow some establish marin rout last 50 year total amount 37 oil tanker have given rise great spill differ part world prestig be last one after accid big human mobilis took place order clean beach rock fauna tri reduc environment consequ serious catastroph these peopl were expos complex mixtur compound contain oil this studi aim determin level environment exposur volatil organ compound voc possibl damag induc popul involv differ clean task appli genotox test sister chromatid exchang sce micronucleus test comet assay four group individu were includ volunt hire manual worker hire highpressur cleaner worker hpw control the higher voc level were associ environ follow last hpw probabl due use highpressur cleaner oil exposur dure clean task has caus increas genotox damag individu comet assay be most sensit biomark detect sex age tobacco consumpt have shown influenc level genet damag while effect use protect devic less notic than expect perhap becaus kind use most adequ

Beatriz Pérez-Cadahía

Blanca Laffon

Eduardo Pásaro

Josefina Méndez

Genetic Damage Induced by Accidental Environmental Pollutants

the alkalin singlecel gel electrophoresi comet assay appli evalu eventu dna damag induc triphenol metabolit benzen 124benzenetriol isol human lymphocyt prior treatment rang from 5 50 supplement glutathion gsh 350 carri out assess whether gsh may have modul effect comet respons the effect fix dose also evalu presenc exogen antioxid vitamin 40 200 addition investig whether polymorph glutathion stransferas gstt1 gene may affect individu level btinduc dna damag vitro for all donor includ present studi produc signific doserespons relationship clear effect gsh preincub seen btinduc respons contrari signific reduct dna damag observ presenc vitamin least 200 although our data suggest some individu differ accord gstt1 genotyp outcom comet assay larg number individu should studi further investig obtain reliabl conclus

M. Pitarque

A. Creus

R. Marcos

Analysis of glutathione and vitamin C effects

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