Antioxidant Capacity, Cytoprotection, and Healing Actions of the Leaf Aqueous Extract of Ocimum suave in Rats Subjected to Chronic and Cold-Restraint Stress Ulcers
Histological presentation of the chronic acetic acid-induced ulcers: (a): histological section of normal rat stomach showing gastric mucosa (GM), intact annular muscles (AMs), and longitudinal muscles (LMs) in the muscularis. (b)–(f) Histological gastric sections of control rats, day 4 after ulceration and vehicle control (see control 2 and 3, Figure 1) showing the superficial loss of substance, glandular destruction (D), lymphocyte infiltration (I), and sclerosis (S). There was edema (E) and fibrosis (F) in the muscularis mucosa, and blood vessels presented intraparietal leucocyte infiltration, with necrosis and venous congestion. (g)–(h) Stomach sections of rats treated with extract (125 mg/kg bw) showing amelioration of gastric tissues, with disappearance of fibrosis but with persistent edema (E) and some glandular destruction (D). (i) Stomach sections of extract-treated rats (250–500 mg/kg bw) after 14-day treatment showing normalization of the mucosa, without glandular destruction and with disappearance of fibrosis, sclerosis, and lymphocyte infiltration. (j): Rats treated with ranitidine showed advanced scar tissue formation, healthy mucosa but with edematous muscularis (E).