Histological and Immunohistochemical Evaluation of Autologous Cultured Bone Marrow Mesenchymal Stem Cells and Bone Marrow Mononucleated Cells in Collagenase-Induced Tendinitis of Equine Superficial Digital Flexor Tendon

Figure 1

Time course description of the study performed over a period of 24 weeks (T-3-T21); US data were recorded immediately prior to collagenase injection to induce tendon injury, recorded as T-3, then 3 weeks later, just prior to injection of either cBMSC or BMMNCS suspension, fibrin glue, or placebo (= saline) into the tendon lesion (T0), and again at 3, 6, 8, 12, 16, 18, and 21 weeks (T3-T21) following tendon treatment. At T21, animals were euthanized and the SDFTs of all four limbs were harvested and processed for histology and immunohistochemistry examination.