Lycopene Prevents Development of Steatohepatitis in Experimental Nonalcoholic Steatohepatitis Model Induced by High-Fat Diet

Table 4

The effects of lycopene supplementation on histopathological changes.

Parameters	Control group ($n=10$)	HFD ($n=10$)	HFD $+$ 2 mg/kg lycopene ($n=9$)	HFD $+$ 4 mg/kg lycopene ($n=10$)
Steatosis (0–4)	—	$\mathrm{1,30}+\mathrm{0,48}$^†	$\mathrm{0,6}\pm \mathrm{0,51}$ *	$\mathrm{0,70}\pm \mathrm{0,48}$ *
İnflammation (cells/mm^2)	2,11±1,07	$\mathrm{12,45}\pm \mathrm{6,0}$^†	$\mathrm{4,50}\pm \mathrm{2,1}$ **	$\mathrm{4,95},\pm \mathrm{3,81}$ **
Necrosis (foci/mm^2)	—	$\mathrm{1,15}\pm \mathrm{0,8}$7^†	$\mathrm{0,72}\pm \mathrm{0,24}$	$\mathrm{0,57}\pm \mathrm{0,38}$
Fibrosis (0–4)	—	$\mathrm{0,50}\pm \mathrm{0,52}$^†	$\mathrm{0,60}\pm \mathrm{0,51}$	$\mathrm{0,20}\pm \mathrm{0,42}$
CYP 2E1 expression	$\mathrm{1,0}\pm \mathrm{0,0}$	$\mathrm{2,60}\pm \mathrm{0,51}$^†	$\mathrm{1,70}\pm \mathrm{0,48}$ **	$\mathrm{1,20}\pm \mathrm{0,42}$ **
α-SMA expression	—	$\mathrm{2,50}\pm \mathrm{0,52}$^†	$\mathrm{1,80}\pm \mathrm{0,62}$ *	$\mathrm{1,40},\pm \mathrm{0,16}$ **

* $P<.05$: versus HFD group, **$P<.01$: versus HFD group; versus HFD group, $†P<.01$: versus control group.