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Veterinary Medicine International
Volume 2010, Article ID 348919, 6 pages
Research Article

Effects of Melatonin on Adrenal Cortical Functions of Indian Goats under Thermal Stress

1Neurophysiology Laboratory, Division of Physiology and Climatology, Indian Veterinary Research Institute, Izatnagar, Bareilly 243122, India
2Scientist, Adaptation Physiology Laboratory, Division of Physiology & Biochemistry, Central Sheep & Wool Research Institute, Avikanagar, Via-Jaipur, Rajasthan 304501, India

Received 26 July 2009; Revised 5 October 2009; Accepted 10 November 2009

Academic Editor: Robert J. Kemppainen

Copyright © 2010 Veerasamy Sejian and Rajendra Swaroop Srivastava. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The study was conducted with the primary objective to establish the influence of melatonin on adrenocortical functions to ameliorate thermal stress in goats. Endocrine secretions and several other blood biochemical parameters reflecting the animals adrenocortical stress response were determined over a one-week period after goats had been exposed to 4 0 C and 60%RH for 10 days. The study was conducted for a period of 17 days in psychrometric chamber. The animals served as self-controls prior to start of the experiment. Blood samples were drawn on day 10 to establish effect of thermal stress. Chemical adrenalectomy was achieved using metyrapone followed by exogenous melatonin treatment. 4 0 C of thermal stress which is quite normal in tropical zone significantly ( 𝑃 . 0 5 ) influenced all parameters except plasma insulin. Metyrapone treatment significantly ( 𝑃 . 0 5 ) affected plasma levels of glucose, total protein, total cholesterol, cortisol, and aldosterone. Metyrapone aggravated thermal stress by decreasing cortisol level in goats. Melatonin treatment at 11:00 AM significantly ( 𝑃 . 0 5 ) influenced plasma levels of glucose, total protein, total cholesterol, cortisol, aldosterone and insulin. Metyrapone treatment aggravated thermal stress although administration of melatonin could ameliorate the condition. This establishes the role of melatonin in relieving thermal stress in goats.