Candida albicans and C. tropicalis Isolates from the Expired Breathes of Captive Dolphins and Their Environments in an Aquarium
Table 5
Antifungal susceptibility and genotypes of C. albicans isolates.
Susceptibility to antifungal drugs
MDR 1
ITSrRNA
Combined
IFM No.
Animal No.
AMPH-B
5-FC
FLCZ
ITZ
MCZ
MCFG
Accession No.
Genotype (1–16)
Accession No.
Genotype (I–XII)
Genotype (A–X)
Dolphin isolates
55372
No. 1 (W)
0.5
<0.125
>64*
>8*
4
<0.03
AB379716
1
AB437006
V
A
55224
No. 3 (S)
0.5
<0.125
>64*
>8*
8
<0.03
AB379697
1
AB436989
VI
B
55374
No. 3 (W)
0.5
<0.125
>64*
>8*
2
<0.03
AB379717
1
AB437007
VI
B
55226
No. 4 (S)
0.25
0.25
32+
8*
2
<0.03
AB379699
16
AB436991
V
C
55376
No. 4 (W)
0.25
0.125
1
0.125
2
<0.03
AB379718
16
AB437008
V
C
55292
No. 5 (S)
0.5
<0.125
64*
8*
2
<0.03
AB379706
1
AB436997
VI
B
55267
No. 9 (S)
0.25
>64*
>64*
>8*
1
<0.03
AB379700
15
AB436992
VI
D
55378
No. 9 (W)
0.25
>64*
>64*
>8*
32
<0.03
AB379719
15
ND
ND
ND
55273
No. 11 (S)
0.25
0.125
>64*
>8*
4
<0.03
AB379701
15
AB436993
VI
D
55274
No. 11 (S)
0.5
<0.125
2
0.125
1
<0.03
AB379702
15
AB436994
V
E
55381
No. 11 (W)
0.25
<0.125
64*
2*
8
<0.03
AB379720
15
AB737009
XI
F
55276
No. 13 (S)
0.25
<0.125
>64*
>8*
4
<0.03
AB379703
7
AB436995
V
G
55382
No. 13 (W)
0.25
<0.125
64*
8*
4
<0.03
AB379721
7
AB437010
V
G
55281
No. 16 (S)
0.125
>64*
>64*
>8*
2
<0.03
AB379704
15
ND
ND
ND
55290
No. 17 (S)
0.5
<0.125
8
0.125
<0.06
<0.03
AB379705
1
AB436996
IX
H
Environmental isolates
55384
Pool-No. 1 (A) (W)
0.5
<0.125
>64*
>8*
2
<0.03
AB379722
1
AB437011
VI
B
55385
Pool-No. 1 (A) (W)
0.5
<0.125
0.125
0.03
0.06
<0.03
AB379723
7
AB437012
V
G
55302
Pool-No. 2 (A) (S)
0.5
<0.125
>64*
>8*
2
<0.03
AB379710
1
AB737000
IX
H
55304
Pool-No. 2 (A) (S)
0.25
<0.125
64*
>8*
2
<0.03
AB379711
1
AB437001
VI
B
55298
Pool-No. 3 (A) (S)
0.5
<0.125
>64*
>8*
2
<0.03
AB379709
1
ND
ND
ND
55295
Pool-No. 4 (B) (S)
0.5
<0.125
4
>8*
2
<0.03
AB379707
1
AB436998
VI
B
55867
Pool-No. 4 (B) (S)
0.5
<0.125
4
2*
2
<0.03
AB379708
1
AB436999
IX
H
55388
Pool-No. 5 (B) (W)
0.25
<0.125
>64*
>8*
16
>16
AB379726
1
AB437015
V
A
55387
Pool-No. 7 (B) (W)
0.25
>64*
>64*
>8*
>32
<0.03
AB379725
15
AB437014
VIII
I
55386
Pool-No. 8 (A) (W)
0.25
<0.125
>64*
>8*
>32
<0.03
AB379724
1
AB437013
VIII
J
55871
Pool-No. 9 (C) (S)
0.5
<0.125
8
1*
2
<0.03
AB379712
15
AB707002
VIII
I
55319
Sea Water (D) (S)
0.25
<0.125
4
0.06
2
<0.03
AB379714
15
AB437004
VIII
I
Staff isolates
55390
Staff-A
0.25
<0.125
>64*
>8*
8
<0.03
AB379727
16
AB437016
V
C
55392
Staff-B
0.5
<0.125
2
0.125
0.5
<0.03
AB379728
11
AB437017
V
K
55395
Staff-C
0.5
<0.125
0.5
0.03
2
<0.03
AB379729
5
AB437018
II
L
Reference isolates
4953
Sputum (J)
0.25
<0.125
0.25
0.03
<0.06
<0.03
AB379730
9
AB437019
I
M
5633
Oral mucosa (J)
0.25
<0.125
0.25
0.03
0.06
<0.03
AB379731
13
AB437020
V
N
5713
Sputum (J)
0.25
<0.125
0.125
0.03
<0.06
<0.03
AB379732
10
AB437021
IV
O
40213
Blood (USA)
0.5
0.25
0.25
0.03
0.06
<0.03
AB379735
2
AB437024
V
P
=ATCC 90028
41419
Sputum (J)
0.25
<0.125
0.25
0.03
0.06
<0.03
AB379736
4
AB437025
X
Q
49764
Oral mucosa (J)
0.5
<0.125
0.25
0.03
0.06
<0.03
AB379741
4
AB437029
V
R
49765
Oral mucosa (J)
0.5
>64*
8
0.06
0.06
<0.03
AB379742
3
AB437030
III
S
49767
Tongue (J)
0.5
<0.125
1
0.06
0.25
<0.03
AB379743
6
AB437034
XII
T
54349
Sputum (J)
0.5
<0.125
0.25
0.03
0.06
<0.03
AB379751
8
AB437039
I
U
54381
Sputum (J)
0.5
<0.125
0.125
0.03
0.125
<0.03
AB379752
14
AB437040
V
V
54604
Clinical isolate (TW)
0.5
1
1
0.125
0.25
<0.03
AB379754
16
AB437041
XII
W
55046
Clinical isolate (J)
0.5
<0.125
0.125
0.03
0.06
<0.03
AB379756
12
AB437043
VII
X
S: collected at August 2006, W: collected at February 2007. J: Japan, USA: the United States of America, TW: Taiwan. A, B, C and D indicated at the environmental isolate indicated the water supply system. AMPH-B: amphotericin B, 5-FC: flucytosine, FLCZ: fluconazole, ITZ: itraconazole, MCZ: miconazole, MCFG: micafungin:
*; resistant, and +; dose-dependent susceptibility based on CLSI M27-A2 protocol [42].
