406275.fig.001a
(a)
406275.fig.001b
(b)
406275.fig.001c
(c)
406275.fig.001d
(d)
Figure 1: Cerebellum, dog. (a) Multifocal thinning of the cerebellar folia. Hematoxylin and eosin stain (HE). Bar: 1 mm. (b) Moderate hypocellularity of the inner granular layer (IG), increased cellularity in the white matter (W), and a well-defined molecular layer (M). HE stain. Bar: 500 μm. (c) Moderate, multifocal depletion and degeneration of purkinje cells (arrow) and partial retention of the external granular layer (EG). HE stain. Bar: 200 μm. (d) Marked astrogliosis evidenced by positive GFAP immunostaining in the external granular layer (EG), molecular layer (M), inner granular layer (IG), and white matter (W). Immunoperoxidase with 3-, 3′-diaminobenzidine with Mayer’s hematoxylin counterstain. Bar: 1 mm.