Research Article
In Vitro Susceptibility of Canine Influenza A (H3N8) Virus to Nitazoxanide and Tizoxanide
Table 1
In vitro activity of nitazoxanide (NTZ) and its active metabolite tizoxanide (TIZ) on clinical isolates of canine influenza virus (CIV).
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EC50 or 90: Concentration (M) of NTZ or TIZ at which a 2-fold (50%) or 10-fold (90%) reduction of viral titer is relative to untreated controls. EC50 and EC90 are expressed as means standard deviation. SI: Selectivity Index (CC50/EC50). Viral titers of three CIV isolates were analyzed using polynomial regression analysis. 95% confidence intervals for each value are displayed in parenthesis. |