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Veterinary Medicine International
Volume 2011, Article ID 629409, 7 pages
Review Article

Xenografting as a Tool to Preserve Endangered Species: Outcomes and Challenges in Model Systems

1Center for Neuroscience and Cell Biology, Department of Life Sciences, University of Coimbra, P.O. Box/Apartado 3046, 3001-401 Coimbra, Portugal
2Centre of Reproductive Medicine and Andrology, University of Münster, Domagkstraße 11, 48149 Münster, Germany

Received 1 June 2010; Accepted 16 August 2010

Academic Editor: Ali Honaramooz

Copyright © 2011 Paula C. Mota et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The use of testis tissue xenografting as a valuable tool to rescue endangered and genetically valuable individuals that die young or otherwise fail to produce sperm has been the subject of much interest. Although the technique has been successfully applied to a wide variety of species, little is known about what determines the outcome. Furthermore, to improve the applicability of xenografting, new methods to preserve and transport testis tissue from valuable animals are emerging. However, one major issue remains: the application of xenografting implies the development of subsequent ART techniques to produce offspring from the recovered material. This paper focuses on these three aspects of testis tissue xenografting as a tool for rescuing endangered and valuable genetic pools.