Hemotoxicity Induced by Chronic Chlorpyrifos Exposure in Wistar Rats: Mitigating Effect of Vitamin C

Table 1

Effect of chronic exposure to soya oil (S/oil), vitamin C (VC), and/or chlorpyrifos (CPF) on pack cell volume (PCV), red blood cell (RBC) and hemoglobin (Hb) concentrations, and erythrocyte indices in Wistar rats.

Parameters	S/oil	VC	CPF	VC+CPF
PCV (%)	42 ± 1.6	44 ± 1.3	35 ± 1.2ab	40 ± 0.95
Hb (g/dL)	14 ± 0.53	15 ± 0.64	12 ± 0.37ab	13 ± 0.31
RBC count (×10^12/L)	5.8 ± 0.49	6.8 ± 0.3	3.7 ± 0.15abc	5.1 ± 0.07d
MCV (fL/cell)	79 ± 11	63 ± 6.0	9.3 ± 3.1b	7.9 ± 3.0
MCH (pg/cell)	25 ± 2.7	24 ± 2.2	33 ± 2.1b	26 ± 0.84
MCHC (g/dL)	33 ± 1.5	33 ± 2.2	34 ± 2.0	33 ± 0.8

^a𝑃<.01 versus soya oil group; ^b𝑃<.01 versus vitamin C group; ^c𝑃<.05 versus vitamin C+chlorpyrifos group; ^d𝑃<.01 versus vitamin C group. Values are mean ± SEM of 5 animals per group. NB-MCV: mean cell volume; MCH: Mean corpuscular hemoglobin; MCHC: Mean corpuscular hemoglobin concentration.