Table of Contents Author Guidelines Submit a Manuscript
Veterinary Medicine International
Volume 2011, Article ID 981410, 9 pages
http://dx.doi.org/10.4061/2011/981410
Research Article

A New Experimental Infection Model in Ferrets Based on Aerosolised Mycobacterium bovis

1Veterinary Sciences Division, Agri-food and Biosciences Institute, Stoney Road, Belfast BT4 3SD, UK
2Department of Infectious Immunology, Statens Serum Institut, 5 Artillerivej, 2300 Copenhagen S, Denmark
3Department of Microbial and Molecular Pathogenesis, Texas A&M University System Health Science Center, College Station, TX 77840-7896, USA

Received 13 January 2011; Revised 14 February 2011; Accepted 16 February 2011

Academic Editor: Mitchell V. Palmer

Copyright © 2011 Lyanne McCallan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. R. J. Delahay, G. J. Wilson, G. C. Smith, and C. L. Cheeseman, “Vaccinating badgers (Meles meles) against Mycobacterium bovis: the ecological considerations,” The Veterinary Journal, vol. 166, no. 1, pp. 43–51, 2003. View at Publisher · View at Google Scholar · View at Scopus
  2. M. A. Chambers, F. Rodgers, R. J. Delahay et al., “Bacillus Calmette-Guerin vaccination reduces the severity and progression of tuberculosis in badgers,” Proceedings of the Royal Society B. In Press. View at Publisher · View at Google Scholar
  3. L. A. L. Corner, E. Costello, S. Lesellier, D. O'Meara, and E. Gormley, “Vaccination of European badgers (Meles meles) with BCG by the subcutaneous and mucosal routes induces protective immunity against endobronchial challenge with Mycobacterium bovis,” Tuberculosis, vol. 88, no. 6, pp. 601–609, 2008. View at Publisher · View at Google Scholar · View at Scopus
  4. S. Lesellier, L. Corner, E. Costello et al., “Antigen specific immunological responses of badgers (Meles meles) experimentally infected with Mycobacterium bovis,” Veterinary Immunology and Immunopathology, vol. 122, no. 1-2, pp. 35–45, 2008. View at Publisher · View at Google Scholar · View at Scopus
  5. J. Dietrich, K. Weldingh, and P. Andersen, “Prospects for a novel vaccine against tuberculosis,” Veterinary Microbiology, vol. 112, no. 2-4, pp. 163–169, 2006. View at Publisher · View at Google Scholar · View at Scopus
  6. T. Kuiken, J. van den Brand, D. van Riel, M. Pantin-Jackwood, and D. E. Swayne, “Comparative pathology of select agent influenza a virus infections,” Veterinary Pathology, vol. 47, no. 5, pp. 893–914, 2010. View at Publisher · View at Google Scholar
  7. S. Pillet, N. Svitek, and V. von Messling, “Ferrets as a model for morbillivirus pathogenesis, complications, and vaccines,” Current Topics in Microbiology and Immunology, vol. 330, pp. 73–87, 2009. View at Publisher · View at Google Scholar
  8. C. J. Sigurdson, C. K. Mathiason, M. R. Perrott et al., “Experimental chronic wasting disease (CWD) in the ferret,” Journal of Comparative Pathology, vol. 138, no. 4, pp. 189–196, 2008. View at Publisher · View at Google Scholar · View at Scopus
  9. J. R. Ragg, H. Moller, and K. A. Waldrup, “The prevalence of bovine tuberculosis (Mycobacterium bovis) infections in feral populations of cats (Felis catus), ferrets (Mustela furo) and stoats (Mustela erminea) in Otago and Southland, New Zealand,” New Zealand Veterinary Journal, vol. 43, no. 7, pp. 333–337, 1995. View at Google Scholar
  10. J. D. Rodgers, N. L. Connery, J. McNair et al., “Experimental exposure of cattle to a precise aerosolised challenge of Mycobacterium bovis: a novel model to study bovine tuberculosis,” Tuberculosis, vol. 87, no. 5, pp. 405–414, 2007. View at Publisher · View at Google Scholar · View at Scopus
  11. R. A. Skuce, S. W. McDowell, T. R. Mallon et al., “Discrimination of isolates of Myobacterium bovis in Northern Ireland on the basis of variable numbers of tandem repeates (VNTRs),” Veterinary Record, vol. 157, no. 17, pp. 501–504, 2005. View at Google Scholar · View at Scopus
  12. G. W. de Lisle, R. P. Kawakami, G. F. Yates, and D. M. Collins, “Isolation of Mycobacterium bovis and other mycobacterial species from ferrets and stoats,” Veterinary Microbiology, vol. 132, no. 3-4, pp. 402–407, 2008. View at Publisher · View at Google Scholar · View at Scopus
  13. S. D. Neill, J. Cassidy, J. Hanna et al., “Detection of Mycobacterium bovis infection in skin test-negative cattle with an assay for bovine interferon-gamma,” Veterinary Record, vol. 135, no. 6, pp. 134–135, 1994. View at Google Scholar · View at Scopus
  14. D. Murphy, E. Gormley, E. Costello, D. O'Meara, and L. A. L. Corner, “The prevalence and distribution of Mycobacterium bovis infection in European badgers (Meles meles) as determined by enhanced post mortem examination and bacteriological culture,” Research in Veterinary Science, vol. 88, no. 1, pp. 1–5, 2010. View at Publisher · View at Google Scholar · View at Scopus
  15. L. A. L. Corner, D. Murphy, and E. Gormley, “Mycobacterium bovis infection in the Eurasian badger (Meles meles): the disease, pathogenesis, epidemiology and control,” Journal of Comparative Pathology, vol. 144, no. 1, pp. 1–24, 2011. View at Publisher · View at Google Scholar
  16. L. A. Corner, “Personal communication,” 2010. View at Google Scholar
  17. C. E. Stager, J. P. Libonati, S. H. Siddiqi et al., “Role of solid media when used in conjunction with the BACTEC system for mycobacterial isolation and identification,” Journal of Clinical Microbiology, vol. 29, no. 1, pp. 154–157, 1991. View at Google Scholar · View at Scopus
  18. L. A. Corner and C. Nicolacopoulos, “Comparison of media used for the primary isolation of Mycobacterium bovis by veterinary and medical diagnostic laboratories,” Australian Veterinary Journal, vol. 65, no. 7, pp. 202–205, 1988. View at Google Scholar · View at Scopus
  19. L. A. Corner, “Post mortem diagnosis of Mycobacterium bovis infection in cattle,” Veterinary Microbiology, vol. 40, no. 1-2, pp. 53–63, 1994. View at Publisher · View at Google Scholar · View at Scopus
  20. C. S. Cox, The Aerobiological Pathway of Organisms, Wiley-Interscience Publications, Chichester, UK, 1987.
  21. D. W. Smith, D. N. McMurray, E. H. Wiegeshaus, A. A. Grover, and G. E. Harding, “Host-parasite relationships in experimental airborne tuberculosis. IV. Early events in the course of infection in vaccinated and nonvaccinated guinea pigs,” American Review of Respiratory Disease, vol. 102, no. 6, pp. 937–949, 1970. View at Google Scholar · View at Scopus
  22. I. W. Lugton, G. Wobeser, R. S. Morris, and P. Caley, “Epidemiology of Mycobacterium bovis infection in feral ferrets (Mustela furo) in New Zealand: II. Routes of infection and excretion,” New Zealand Veterinary Journal, vol. 45, no. 4, pp. 151–157, 1997. View at Google Scholar · View at Scopus
  23. J. Gallagher, R. Monies, M. Gavier-Widen, and B. Rule, “Role of infected, non-diseased badgers in the pathogenesis of tuberculosis in the badger,” Veterinary Record, vol. 142, no. 26, pp. 710–714, 1998. View at Google Scholar · View at Scopus
  24. J. Gallagher and P. A. Jenkins, “Mycobacterial diseases,” in Zoonoses, pp. 155–164, Oxford University Press, Oxford, UK, 1998. View at Google Scholar
  25. R. S. Clifton-Hadley, “Badgers, bovine tuberculosis and the age of reason,” The British Veterinary Journal, vol. 152, no. 3, pp. 243–246, 1996. View at Google Scholar · View at Scopus
  26. L. A. Corner, A. C. Trajstman, and K. Lund, “Determination of the optimum concentration of decontaminants for the primary isolation of Mycobacterium bovis,” New Zealand Veterinary Journal, vol. 43, pp. 129–133, 1995. View at Google Scholar
  27. J. R. Ragg, K. A. Waldrup, and H. Moller, “The distribution of gross lesions of tuberculosis caused by Mycobacterium bovis in feral ferrets (Mustela furo) from Otago, New Zealand,” New Zealand Veterinary Journal, vol. 43, no. 7, pp. 338–341, 1995. View at Google Scholar
  28. I. W. Lugton, G. Wobeser, R. S. Morris, and P. Caley, “Epidemiology of Mycobacterium bovis infection in feral ferrets (Mustela furo) in New Zealand: I. Pathology and diagnosis,” New Zealand Veterinary Journal, vol. 45, no. 4, pp. 140–150, 1997. View at Google Scholar · View at Scopus
  29. J. M. Pollock, J. D. Rodgers, M. D. Welsh, and J. McNair, “Pathogenesis of bovine tuberculosis: the role of experimental models of infection,” Veterinary Microbiology, vol. 112, no. 2-4, pp. 141–150, 2006. View at Publisher · View at Google Scholar · View at Scopus
  30. M. L. Cross, R. E. Labes, and C. G. Mackintosh, “Oral infection of ferrets with virulent Mycobacterium bovis or Mycobacterium avium: susceptibility, pathogenesis and immune response,” Journal of Comparative Pathology, vol. 123, no. 1, pp. 15–21, 2000. View at Publisher · View at Google Scholar · View at Scopus
  31. T. Qureshi, R. E. Labes, M. L. Cross, J. F. T. Griffin, and C. G. Mackintosh, “Partial protection against oral challenge with Mycobacterium bovis in ferrets (Mustela furo) following oral vaccination with BCG,” International Journal of Tuberculosis and Lung Disease, vol. 3, no. 11, pp. 1025–1033, 1999. View at Google Scholar · View at Scopus