Morphological Changes in the Bone Marrow of the Dogs with Visceral Leishmaniasis

Figure 1

Photomicrographs of the bone marrow of dogs with visceral leishmaniasis. (a) Granuloma (*), megakaryocytic emperipolesis (arrow, (a1), group O), and dysplastic megakaryocytes ((a2), group O). (b) Bone marrow with severe aplasia (group A); hematoxylin and eosin, objective 40x. (c) Immunolabeling of amastigote forms of L. chagasi in macrophages (*); detail of megakaryocytic emperipolesis with an immunolabeled amastigote form (arrow, (c1); symptomatic dog); streptavidin-biotin-peroxidase complex, objective 40x.