Genetic Association Analysis of Paratuberculosis Forms in Holstein-Friesian Cattle
Table 2
Association results from apparently free versus latent PTB logistic regression analysis.
Gene
SNP
Model
Genotypes
Percentage of apparently free
Percentage of latent PTB
CD209
rs208222804
Codominant
T/T; T/C; C/C
51.0; 41.8; 7.2
62.5; 34.1; 3.4
0.0096
Dominant
T/T; T/C-C/C
51.0; 49.0
62.5; 37.5
0.0058
Recessive
T/T-T/C; C/C
92.8; 7.2
96.6; 3.4
0.0471
Log-additive
0, 1, 2
59.1
40.9
0.0024*
rs209491136
Recessive
A/A-A/G; G/G
93.4; 6.6
97.0; 3.0
0.0469
rs211654540
Codominant
A/A; A/G; G/G
51.8; 41.3; 6.9
61.8; 34.8; 3.4
0.0221
Dominant
A/A; A/G-G/G
51.8; 48.2
61.8; 38.2
0.0152
Log-additive
0, 1, 2
58.8
41.2
0.0063
rs208814257
Dominant
C/C; C/G-G/G
49.8; 50.2
59.0; 41.0
0.0279
Log-additive
0, 1, 2
58.9
41.1
0.0148
rs210748127
Codominant
T/T; T/C; C/C
48.8; 42.5; 8.7
56.3; 40.3; 3.5
0.0158
Recessive
T/T-T/C; C/C
91.3; 8.7
96.5; 3.5
0.0088
Log-additive
0, 1, 2
59.0
41.0
0.0115
SLC11A1
rs109453173
Overdominant
C/C-G/G; C/G
69.0; 31.0
60.4; 39.6
0.0348
SP110
rs110480812
Codominant
A/A; A/G; G/G
54.8; 36.6; 8.6
45.9; 48.9; 5.2
0.0095
Dominant
A/A; A/G-G/G
54.8; 45.2
45.9; 54.1
0.0356
Overdominant
A/A-G/G; A/G
63.4; 36.6
51.1; 48.9
0.0035
TLR2
rs109971269
Overdominant
T/T-C/C; C/T
74.3; 25.7
81.1; 18.9
0.0477
rs43706433
Codominant
A/A; A/G; G/G
60.5; 34.4; 5.0
70.0; 25.2; 4.8
0.0484
Dominant
A/A; A/G-G/G
60.5; 39.5
70.0; 30.0
0.0168
Overdominant
A/A-G/G; A/G
65.6; 34.4
74.8; 25.2
0.0165
Log-additive
0, 1, 2
59.4
40.6
0.0418
All models were adjusted for age at slaughter (years). SNPs and genetic models with a nominal P value are only shown. Significant association (P < 0.0034 after permutation procedure). Odds ratio (OR): 0.64, 95% CI: 0.48–0.86. Threshold of significance for genetic models (after permutation procedure): ; ; ; ; .
