Temporal Bacteriostatic Effect and Growth Factor Loss in Equine Platelet Components and Plasma Cultured with Methicillin-Sensitive and Methicillin-Resistant Staphylococcus aureus: A Comparative In Vitro Study

Table 1

Median (interquartile ranges (IR)) for both methicillin-sensitive Staphylococcus aureus (MSSA) and methicillin-resistant S. aureus (MRSA) (CFU/mL × 10⁸) (1 : 100 × 10³ dilution) for every blood component over time.

Blood components	MSSA	MRSA	MSSA	MRSA
	6 hours		24 hours
Positive control group (PCG)	280 (330)^a	425 (1007.5)^a	2400 (1595)^a	2580 (1135)^a
Platelet-rich plasma (PRP)	0.0 (2.5)^b	0.0 (0.0)^b,c,d	55 (95)^b,e	570 (640)^B
Platelet-rich gel (PRG)	0.0 (0.0)^b	0.0 (10)^b	265 (455)^b,d,f	410 (470)
Leukocyte-poor plasma (LPP)	0.0 (10)^b	0.0 (10)^b,d	80 (112.5)^b	535 (285)^B
Leukocyte-poor gel (LPG)	0.0 (0)^b	5.0 (30)^b,A	140 (450)^b	350 (462)^b
Plasma	0.0 (10)^b	10 (22.5)^b,A	75 (75)^b	305 (395)^b,C
Heat inactivated plasma (IP)	15 (52.5)	45 (122)	580 (610)	645 (260)

Different lowercase letters represent significant differences between each treatment group at each specific time. ^aSignificantly different from all treatments ( > 0.001). ^bSignificantly different from IP ( > 0.001). ^cSignificantly different from LPG ( > 0.05). ^dSignificantly different from plasma ( > 0.05). ^eSignificantly different from PRG ( > 0.05). ^fSignificantly different from LPP ( > 0.05). Different capital letters represent significant differences in the same row for a specific treatment group in relation to both bacteria during a specific period of time. ^A > 0.05. ^B > 0.001. ^C > 0.01.