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| Galactogogue drug | Proposed mechanism | Doses and dosage form | Adverse effects | Half-life |
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| Metoclopramide | D2R antagonist, increase PRL secretion [2]. | Human: 10 mg PO TID [31]. Canine/feline: 0.1-0.2 mg/kg, SC TID [32]. | Humans: several gastrointestinal disorders, insomnia severe depression, and seizures and in infants that consume milk from treated mothers causing intestinal discomfort [2]. | Humans: 156.7 minutes [29].
Dogs: 90 minutes [30]. |
|
| Domperidone | D2R antagonist, increase PRL secretion [2]. | Human: 10 mg PO TID [37]. Canine/feline: 2.2 mg/kg SC, every 12 hours for 4–6 days [36]. Equine: 1.1 mg/kg PO BID [38]. | Humans: xerostomia, gastrointestinal disorders, cardiac arrhythmia, and sudden death [2]. | Humans: 7.5 hours [36]. |
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| Chlorpromazine | D2R antagonist, increase PRL secretion [2]. | Human: 25 mg PO TID [42]. Rat: 15 mg/kg [41]. | Humans: extrapyramidal symptoms in mothers and lethargy in infants [2, 40]. Feline: in high doses tremors, shivering, rigidity, and loss of the righting, reflexes, lethargy, diarrhea, and loss of anal sphincter tone [30]. Equine: ataxic reactions, excitation, panic reactions and violent consequences, sedation [30], and phototoxic reactions [45, 46]. | Humans: 16–30 hours [43]. |
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| Sulpiride | D2R antagonist, increase PRL secretion [2]. | Human: 50 mg PO TID [49]. Equine: 1.1 mg/kg PO BID [54] or 0.5 BID IM [38]. | Humans: headache, fatigue, extrapyramidal symptoms, acute dystonic reactions, and endocrine disruption [2, 50]. | Dogs: 1.6–3.4 hours [51].
Humans: 7.15 hours [53]. |
|
| Oxytocin | Induce milk ejection and this promotes milk synthesis by FIL decrease [28]. | Canine and feline: 0.5–2.0 IU/kg dose SC EM [32]. Bovine: 20 IU SC EM [70]. Sheep and goat: 1–5 IU EM [71]. Swine: 0.025 and 0.05 IU IV EM [72]. Equine: 20 UI IM EM [73]. | When used appropriately at reasonable dosages, oxytocin rarely causes significant adverse reactions [30]. Result of using the drug in inappropriate individuals (adequate physical exam and monitoring of patient are essential) or at too high doses [26]. In high doses they may cause discomfort, uterine cramping, hazardous of uterine rupture, and fetuses-placental compromise. [30]. | Goat: 22 minutes [61].
Swine: 127 seconds [62].
Rat: 1.46 minutes [63].
Bovine: 7–9 minutes and 25 minutes [64, 65].
Equine: 6.8 minutes [66].
Humans: 272 seconds [67]. |
|
| Recombinant bovine somatotropin (rBST) | Increase basal metabolic rate and nutrients bioavailability, in mammary gland
Increase MEC proliferation, survival and milk synthesis [92]. | Bovine: 500 mg SC every 14 days [5]. | Bovine: low pregnancy rates, increased open days [94], increase incidences of retained placenta [95], clinical and subclinical, reduced food intake, allergic reactions, laminitis digestive disorders [5], decreased hemoglobin and hematocrit [98], and mastitis [96, 97]. | Bovine: 54.8 minutes [93]. |
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| Thyrotropin releasing hormone (TRH) | Increase PRL blood levels [102]. | Humans: 20 mg PO TID [105]. | Human: hyperthyroidism and brief episodes of sweating [106, 108]. | Rat: 4.16 minutes [109]. |
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| Medroxyprogesterone | Not reported | Humans: 150 mg IM every 3 months [122]. | Human: amenorrhea [121]. | Human: 40–60 hrs [119]. |
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