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Veterinary Medicine International
Volume 2015, Article ID 932080, 8 pages
http://dx.doi.org/10.1155/2015/932080
Research Article

Effect of Moxidectin Treatment at Peripartum on Gastrointestinal Parasite Infections in Ewes Raised under Tropical Andes High Altitude Conditions

1Genetic Institute, National University of Colombia, Carrera 30 No. 45-03, Edificio 426, Bogotá D.C., Colombia
2Unit of Integrated Veterinary Research, Department of Veterinary Medicine, University of Namur, rue de Bruxelles 61, 5000 Namur, Belgium
3Faculty of Veterinary Medicine and Animal Science, National University of Colombia, Carrera 30 No. 45-03, Edificio 481, Bogotá D.C., Colombia
4Faculty of Veterinary Medicine, Cooperative University of Colombia, Calle 30 No. 33-51, Bucaramanga, Colombia
5Research Unit of Epidemiology and Risk Analysis Applied to Veterinary Sciences (UREAR), Fundamental and Applied Research for Animal and Health (FARAH), University of Liège, boulevard de Colonster 20, 4000 Liège, Belgium

Received 19 January 2015; Revised 15 April 2015; Accepted 22 April 2015

Academic Editor: Guillermo Virkel

Copyright © 2015 J. J. Vargas-Duarte et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

This study tested the impact of moxidectin at peripartum on nematode fecal egg count (FEC) and clinical parameters on ewes in the high altitude tropical Andes of Colombia. FEC and clinical evaluations were performed on 9 occasions in 43 naturally infected ewes before and during gestation and after lambing. Moxidectin (Mox, 200 µg kg−1) was applied at late pregnancy (T1, ) or 48 hours after parturition (T2, ). 14 untreated ewes served as controls (C). Suckling lambs remained untreated and underwent four clinical and parasitological evaluations until 8 weeks after birth. Mox efficacy equaled 99.3% (T1) and 96.9% (T2). Highest mean FEC value reflecting periparturient nematode egg rise (PPER) was recorded in C ewes at 4–6 weeks after lambing. Significant FEC reductions were found in T1 (94.8%) and T2 (96.7%) ewes . All lambs showed a significant and ewes-group independent increase in FEC before weaning . Clinical parameters (anemia and diarrhea) showed time- and treatment-related differences . Monitoring of FEC and clinical parameters linked to gastrointestinal parasite infections allowed demonstrating that postpartum or preweaning are two critical periods to nematode infection for sheep raised under tropical Andes high altitude conditions. Use of Mox as anthelmintic treatment prevented PPER.