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Veterinary Medicine International
Volume 2018, Article ID 7517359, 8 pages
https://doi.org/10.1155/2018/7517359
Research Article

Serum Symmetric Dimethylarginine as an Early Marker of Excretory Dysfunction in Canine Leishmaniosis (L. infantum) Induced Nephropathy

1Fundació Hospital Clínic Veterinari, Universitat Autònoma de Barcelona, Barcelona, Spain
2Departament de Medicina i Cirurgia Animals, Facultat de Veterinària, Universitat Autònoma de Barcelona, Barcelona, Spain
3IDEXX Laboratorios, Barcelona, Spain

Correspondence should be addressed to Laia Solano-Gallego; tac.bau@onalos.aial

Received 27 December 2017; Revised 19 March 2018; Accepted 29 March 2018; Published 13 May 2018

Academic Editor: Remo Lobetti

Copyright © 2018 Esther Torrent et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. G. Baneth, A. F. Koutinas, L. Solano-Gallego, P. Bourdeau, and L. Ferrer, “Canine leishmaniosis—new concepts and insights on an expanding zoonosis: part one,” Trends in Parasitology, vol. 24, no. 7, pp. 324–330, 2008. View at Publisher · View at Google Scholar · View at Scopus
  2. C. L. Barbiéri, “Immunology of canine leishmaniasis,” Parasite Immunology, vol. 28, no. 7, pp. 329–337, 2006. View at Publisher · View at Google Scholar · View at Scopus
  3. S. Hosein, D. P. Blake, and L. Solano-Gallego, “Insights on adaptive and innate immunity in canine leishmaniosis,” Parasitology, vol. 144, no. 1, pp. 95–115, 2017. View at Publisher · View at Google Scholar · View at Scopus
  4. C. G. Nieto, M. García-Alonso, J. M. Requena et al., “Analysis of the humoral immune response against total and recombinant antigens of Leishmania infantum: Correlation with disease progression in canine experimental leishmaniasis,” Veterinary Immunology and Immunopathology, vol. 67, no. 2, pp. 117–130, 1999. View at Publisher · View at Google Scholar · View at Scopus
  5. E. Pinelli, R. Killick-Kendrick, J. Wagenaar, W. Bernadina, G. Del Real, and J. Ruitenberg, “Cellular and humoral immune responses in dogs experimentally and naturally infected with Leishmania infantum,” Infection and Immunity, vol. 62, no. 1, pp. 229–235, 1994. View at Google Scholar · View at Scopus
  6. A. Poli, F. Abramo, F. Mancianti, M. Nigro, S. Pieri, and A. Bionda, “Renal involvement in canine leishmaniasis. A light-microscopic, immunohistochemical and electron-microscopic study,” Nephron, vol. 57, no. 4, pp. 444–452, 1991. View at Publisher · View at Google Scholar · View at Scopus
  7. L. Aresu, S. Benali, S. Ferro et al., “Light and Electron Microscopic Analysis of Consecutive Renal Biopsy Specimens From Leishmania-Seropositive Dogs,” Veterinary Pathology, vol. 50, no. 5, pp. 753–760, 2013. View at Publisher · View at Google Scholar · View at Scopus
  8. A. F. Koutinas and C. K. Koutinas, “Pathologic mechanisms underlying the clinical findings in canine Leishmaniosis due to Leishmania infantum/chagasi,” Veterinary Pathology, vol. 51, no. 2, pp. 527–538, 2014. View at Publisher · View at Google Scholar · View at Scopus
  9. K. Plevraki, A. F. Koutinas, H. Kaldrymidou et al., “Effects of allopurinol treatment on the progression of chronic nephritis in canine leishmaniosis (Leishmania infantum),” Journal of Veterinary Internal Medicine, vol. 20, no. 2, pp. 228–233, 2006. View at Publisher · View at Google Scholar · View at Scopus
  10. A. Zatelli, M. Borgarelli, R. Santilli et al., “Glomerular lesions in dogs infected with Leishmania organisms,” American Journal of Veterinary Research, vol. 64, no. 5, pp. 558–561, 2003. View at Publisher · View at Google Scholar · View at Scopus
  11. S. Paltrinieri, L. Gradoni, X. Roura, A. Zatelli, and E. Zini, “Laboratory tests for diagnosing and monitoring canine leishmaniasis,” Veterinary Clinical Pathology, vol. 45, no. 4, pp. 552–578, 2016. View at Publisher · View at Google Scholar · View at Scopus
  12. O. Cortadellas, M. J. Fernández Del Palacio, J. Talavera, and A. Bayón, “Glomerular filtration rate in dogs with leishmaniasis and chronic kidney disease,” Journal of Veterinary Internal Medicine, vol. 22, no. 2, pp. 293–300, 2008. View at Publisher · View at Google Scholar · View at Scopus
  13. P. Ciaramella, G. Oliva, R. de Luna et al., “A retrospective clinical study of canine leishmaniasis in 150 dogs naturally infected by Leishmania infantum,” Veterinary Record, vol. 141, no. 21, pp. 539–543, 1997. View at Publisher · View at Google Scholar · View at Scopus
  14. X. Roura, A. Fondati, G. Lubas et al., “Prognosis and monitoring of leishmaniasis in dogs: A working group report,” The Veterinary Journal, vol. 198, no. 1, pp. 43–47, 2013. View at Publisher · View at Google Scholar · View at Scopus
  15. M. Pierantozzi, X. Roura, S. Paltrinieri, M. Poggi, and A. Zatelli, “Variation of proteinuria in dogs with leishmaniasis treated with meglumine antimoniate and allopurinol: a retrospective study,” Journal of the American Animal Hospital Association, vol. 49, no. 4, pp. 231–236, 2013. View at Publisher · View at Google Scholar · View at Scopus
  16. L. Solano-Gallego, A. Koutinas, G. Miró et al., “Directions for the diagnosis, clinical staging, treatment and prevention of canine leishmaniosis,” Veterinary Parasitology, vol. 165, no. 1-2, pp. 1–18, 2009. View at Publisher · View at Google Scholar · View at Scopus
  17. J. T. Kielstein, S. R. Salpeter, S. M. Bode-Boeger, J. P. Cooke, and D. Fliser, “Symmetric dimethylarginine (SDMA) as endogenous marker of renal function—a meta-analysis,” Nephrology Dialysis Transplantation , vol. 21, no. 9, pp. 2446–2451, 2006. View at Publisher · View at Google Scholar · View at Scopus
  18. M. B. Nabity, G. E. Lees, M. M. Boggess et al., “Symmetric dimethylarginine assay validation, stability, and evaluation as a marker for the early detection of chronic kidney disease in dogs,” Journal of Veterinary Internal Medicine, vol. 29, no. 4, pp. 1036–1044, 2015. View at Publisher · View at Google Scholar · View at Scopus
  19. J. A. Hall, M. Yerramilli, E. Obare, M. Yerramilli, K. Almes, and D. E. Jewell, “Serum Concentrations of Symmetric Dimethylarginine and Creatinine in Dogs with Naturally Occurring Chronic Kidney Disease,” Journal of Veterinary Internal Medicine, vol. 30, no. 3, pp. 794–802, 2016. View at Publisher · View at Google Scholar · View at Scopus
  20. D. P. Dahlem, R. Neiger, A. Schweighauser et al., “Plasma Symmetric Dimethylarginine Concentration in Dogs with Acute Kidney Injury and Chronic Kidney Disease,” Journal of Veterinary Internal Medicine, vol. 31, no. 3, pp. 799–804, 2017. View at Publisher · View at Google Scholar · View at Scopus
  21. J. A. Hall, M. Yerramilli, E. Obare, M. Yerramilli, L. D. Melendez, and D. E. Jewell, “Relationship between lean body mass and serum renal biomarkers in healthy dogs,” Journal of Veterinary Internal Medicine, vol. 29, no. 3, pp. 808–814, 2015. View at Publisher · View at Google Scholar · View at Scopus
  22. C. Zoccali, R. Maas, S. Cutrupi et al., “Asymmetric dimethyl-arginine (ADMA) response to inflammation in acute infections,” Nephrology Dialysis Transplantation , vol. 22, no. 3, pp. 801–806, 2007. View at Publisher · View at Google Scholar · View at Scopus
  23. S. Blackwell, D. S. J. O'Reilly, D. Reid, and D. Talwar, “Plasma dimethylarginines during the acute inflammatory response,” European Journal of Clinical Investigation, vol. 41, no. 6, pp. 635–641, 2011. View at Publisher · View at Google Scholar · View at Scopus
  24. P. Prusevich, D. Patch, E. Obare et al., “Validation of a novel high throughput immunoassay for the quantitation of symmetric dimethylarginine (SDMA),” Clinical Chemistry, vol. 61, no. S10, p. S135, 2015. View at Google Scholar
  25. IRIS (International Renal Interest Society), “Staging of CKD guidelines,” http://iris-kidney.com/pdf/003-5559.001-iris-website-staging-of-ckd-pdf_220116-final.pdf.
  26. L. Solano-Gallego, L. Di Filippo, L. Ordeix et al., “Early reduction of Leishmania infantum-specific antibodies and blood parasitemia during treatment in dogs with moderate or severe disease,” Parasites & Vectors, vol. 9, no. 1, article no. 235, 2016. View at Publisher · View at Google Scholar · View at Scopus
  27. L. Ordeix, A. Dalmau, M. Osso, J. Llull, S. Montserrat-Sangrà, and L. Solano-Gallego, “Histological and parasitological distinctive findings in clinically-lesioned and normal-looking skin of dogs with different clinical stages of leishmaniosis,” Parasites & Vectors, vol. 10, no. 1, article no. 121, 2017. View at Publisher · View at Google Scholar · View at Scopus
  28. D. Patch, E. Obare, P. Prusevich, H. Xie, and M. Yerramilli, “High throughput immunoassay for kidney function biomarker symmetric dimethylarginine (SDMA),” Clinical Chemistry, vol. 61, p. S135, 2015. View at Google Scholar
  29. C. Trumel, A. Diquélou, H. Lefebvre, and J.-P. Braun, “Inaccuracy of routine creatinine measurement in canine urine,” Veterinary Clinical Pathology, vol. 33, no. 3, pp. 128–132, 2004. View at Publisher · View at Google Scholar · View at Scopus
  30. IDEXX Laboratories, “IDEXX SDMA® Test Algorithm,” https://www.idexx.com/small-animal-health/products-and-services/sdma-results-chart.html.
  31. J. A. Hokamp and M. B. Nabity, “Renal biomarkers in domestic species,” Veterinary Clinical Pathology, vol. 45, no. 1, pp. 28–56, 2016. View at Publisher · View at Google Scholar · View at Scopus
  32. B.-S. Choi, H.-S. Moon, S.-H. Seo, and C. Hyun, “Evaluation of serum cystatin-C and symmetric dimethylarginine concentrations in dogs with heart failure from chronic mitral valvular insufficiency,” Journal of Veterinary Medical Science, vol. 79, no. 1, pp. 41–46, 2017. View at Publisher · View at Google Scholar · View at Scopus
  33. L. Pardo-Marín, S. Martínez-Subiela, J. Pastor et al., “Evaluation of various biomarkers for kidney monitoring during canine leishmaniosis treatment,” BMC Veterinary Research, vol. 13, no. 1, article no. 31, 2017. View at Publisher · View at Google Scholar · View at Scopus
  34. W. E. Feeman III, C. G. Couto, and T. L. Gray, “Serum creatinine concentrations in retired racing greyhounds,” Veterinary Clinical Pathology, vol. 32, no. 1, pp. 40–42, 2003. View at Publisher · View at Google Scholar · View at Scopus
  35. J. Martinez, C. Kellogg, M. C. Iazbik et al., “The Renin-Angiotensin-Aldosterone System in Greyhounds and Non-Greyhound Dogs,” Journal of Veterinary Internal Medicine, vol. 31, no. 4, pp. 988–993, 2017. View at Publisher · View at Google Scholar · View at Scopus
  36. U. Bonfanti, E. Zini, E. Minetti, and A. Zatelli, “Free light-chain proteinuria and normal renal histopathology and function in 11 dogs exposed to Leishmania infantum, Ehrlichia canis, and Babesia canis,” Journal of Veterinary Internal Medicine, vol. 18, no. 5, pp. 618–624, 2004. View at Publisher · View at Google Scholar · View at Scopus
  37. M. Pumarola, L. Brevik, J. Badiola, A. Vargas, M. Domingo, and L. Ferrer, “Canine leishmaniasis associated with systemic vasculitis in two dogs,” Journal of Comparative Pathology, vol. 105, no. 3, pp. 279–286, 1991. View at Publisher · View at Google Scholar · View at Scopus
  38. E. Torrent, M. Leiva, J. Segalés et al., “Myocarditis and generalised vasculitis associated with leishmaniosis in a dog,” Journal of Small Animal Practice, vol. 46, no. 11, pp. 549–552, 2005. View at Publisher · View at Google Scholar · View at Scopus
  39. P. Silvestrini, M. Piviani, J. Alberola et al., “Serum cardiac troponin I concentrations in dogs with leishmaniasis: Correlation with age and clinicopathologic abnormalities,” Veterinary Clinical Pathology, vol. 41, no. 4, pp. 568–574, 2012. View at Publisher · View at Google Scholar · View at Scopus
  40. F. A. Rosa, J. H. A. Leite, E. T. Braga et al., “Cardiac lesions in 30 dogs naturally infected with Leishmania infantum chagasi,” Veterinary Pathology, vol. 51, no. 3, pp. 603–606, 2014. View at Publisher · View at Google Scholar · View at Scopus
  41. L. Martínez-Hernández, D. Casamian-Sorrosal, R. Barrera-Chacón et al., “Comparison of myocardial damage among dogs at different stages of clinical leishmaniasis and dogs with idiopathic chronic kidney disease,” The Veterinary Journal, vol. 221, pp. 1–5, 2017. View at Publisher · View at Google Scholar · View at Scopus
  42. M. Kopke, R. Burchell, C. Ruaux, S. Burton, N. Lopez-Villalobos, and A. Gal, “Variability of Symmetric Dimethylarginine in Apparently Healthy Dogs,” Journal of Veterinary Internal Medicine, vol. 32, no. 2, pp. 736–742, 2018. View at Publisher · View at Google Scholar