Serum Symmetric Dimethylarginine as an Early Marker of Excretory Dysfunction in Canine Leishmaniosis (L. infantum) Induced Nephropathy

Table 1

Comparison of age, creatinine, and SDMA concentrations and UPC on the day of diagnosis of leishmaniosis for Group A versus Group B dogs.

	Group A (median and range)	Group B (median and range)
	Age (months)	42 (5–120)		62 (23–156)	0.14
Creatinine (mg/dL)	0.9 (0.7–1.3)	1.3 (0.8–3.6)	0.01
SDMA (µg/dL)	12 (8–22)	17 (9–42)	0.018
UPC	0.28 (0.08–3.19)	4.15 (0.17–13.9)	<0.0001

Group A: dogs with no evidence of renal disease based on the IRIS staging for CKD [25] after six months of diagnosis of leishmaniosis. Group B: dogs with CKD classified as IRIS stage 1 to stage 3 and dogs euthanized or dead due to renal disease after six months of diagnosis of leishmaniosis. : significance level (Mann–Whitney test). : number of dogs; UPC: urinary protein/creatinine ratio.