Effects of Eplerenone on Blood Pressure and Echocardiographic and Serum Biochemical Variables in Five Healthy Dogs: A Pilot Study
Table 3
Aortic ejection flow velocity (AEV), velocity time integral (VTI), stroke volume (SV), cardiac output (CO), systolic blood pressure (SBP), diastolic blood pressure (DBP), and mean blood pressure (MBP) values after eplerenone (EP) administration in dogs.
Variables
Group
Time after EP administration (weeks)
0
1
2
4
AEV (cm/s)
EP 2.5
81.4 ± 5.4
68.3 ± 5.7
73.3 ± 3.3
76.2 ± 3.4
EP 5
77.7 ± 4.9
68.7 ± 4.0
66.1 ± 2.6
66.7 ± 3.0
EP 10
71.3 ± 3.3
67.5 ± 2.6
67.3 ± 4.3
67.4 ± 2.7
VTI (cm)
EP 2.5
9.0 ± 0.6
7.6 ± 0.6
7.8 ± 0.4
7.9 ± 0.4
EP 5
9.4 ± 0.4
7.6 ± 0.3a
7.8 ± 0.4a
7.6 ± 0.4a
EP 10
8.7 ± 0.1
7.7 ± 0.2
7.8 ± 0.5
7.4 ± 0.5
SV (mL)
EP 2.5
9.1 ± 0.5
7.8 ± 0.5
7.8 ± 0.6
7.5 ± 0.3
EP 5
9.3 ± 0.4
7.2 ± 0.3b
7.6 ± 0.3a
7.5 ± 0.4a
EP 10
9.2 ± 0.5
7.9 ± 0.2
7.7 ± 0.3a
7.4 ± 0.4a
CO (L/min)
EP 2.5
1.13 ± 0.14
0.84 ± 0.11
0.74 ± 0.07a
0.65 ± 0.03a
EP 5
0.87 ± 0.11
0.67 ± 0.07
0.64 ± 0.06
0.65 ± 0.05
EP 10
0.79 ± 0.08
0.72 ± 0.06
0.66 ± 0.04
0.60 ± 0.04
SBP (mmHg)
EP 2.5
121 ± 3.6
117 ± 4.3
111 ± 4.0
114 ± 4.8
EP 5
123 ± 5.0
113 ± 4.5
113 ± 5.5
111 ± 5.2
EP 10
119 ± 7.6
108 ± 6.3
105 ± 4.6
96 ± 4.4cd
DBP (mmHg)
EP 2.5
74 ± 2.5
65 ± 2.7
80 ± 7.8
72 ± 5.8
EP 5
71 ± 4.7
55 ± 4.0a
60 ± 3.6c
60 ± 2.2
EP 10
71 ± 3.3
59 ± 6.5
61 ± 3.0
60 ± 3.6
MBP (mmHg)
EP 2.5
94 ± 2.5
85 ± 4.1
88 ± 6.9
89 ± 4.9
EP 5
92 ± 2.6
73 ± 4.4a
78 ± 4.9
76 ± 2.9ac
EP 10
89 ± 3.3
76 ± 5.2
77 ± 3.7
72 ± 2.1ac
Each value represents the mean ± standard error (). EP 2.5, 5, and 10: eplerenone 2.5, 5, and 10 mg/kg, respectively. a,bValue differs significantly (a;b) from the baseline (time 0) value. cValue differs significantly from the EP 2.5 group at .dValue differs significantly from the EP 5 group at .
